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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qcq 3Q0 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.990
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.978
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.965
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.955
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.942
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.935
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.930
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.929
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.702
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.683
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.679
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
3nuu JOZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
3q3b 55EGlycogen synthase kinase-3 beta 2.7.11.26 0.673
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
4nka 2K7Fibroblast growth factor receptor 1 / 0.669
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.666
3pxy JWSCyclin-dependent kinase 2 2.7.11.22 0.660
3w16 P9JAurora kinase A 2.7.11.1 0.660
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
4f64 0S8Fibroblast growth factor receptor 1 / 0.658
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
1bx6 BA1cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.651
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.650
4f63 0S7Fibroblast growth factor receptor 1 / 0.650