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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pi5 3P5 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3pi5 3P5Beta-secretase 1 3.4.23.46 1.201
3qbh QBHBeta-secretase 1 3.4.23.46 1.024
3vg1 0GTBeta-secretase 1 3.4.23.46 0.932
4lxa 1YSBeta-secretase 1 3.4.23.46 0.923
3vf3 0GSBeta-secretase 1 3.4.23.46 0.903
4lxk 1YTBeta-secretase 1 3.4.23.46 0.892
4lxm 1YUBeta-secretase 1 3.4.23.46 0.863
4d89 BXDBeta-secretase 1 3.4.23.46 0.853
2vnm CM8Beta-secretase 1 3.4.23.46 0.840
3cib 314Beta-secretase 1 3.4.23.46 0.836
3veu 0GOBeta-secretase 1 3.4.23.46 0.833
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.828
3lpj Z75Beta-secretase 1 3.4.23.46 0.822
2vnn CM7Beta-secretase 1 3.4.23.46 0.819
2viz VG4Beta-secretase 1 3.4.23.46 0.814
2xfi XFIBeta-secretase 1 3.4.23.46 0.811
2iqg F2IBeta-secretase 1 3.4.23.46 0.810
2xfk AA9Beta-secretase 1 3.4.23.46 0.809
2vj7 VG6Beta-secretase 1 3.4.23.46 0.803
4exg 916Beta-secretase 1 3.4.23.46 0.801
4k9h 1QUBeta-secretase 1 3.4.23.46 0.798
4ke0 1R8Beta-secretase 1 3.4.23.46 0.798
2viy VG3Beta-secretase 1 3.4.23.46 0.792
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.789
3qi1 C6ABeta-secretase 1 3.4.23.46 0.785
2xfj VG5Beta-secretase 1 3.4.23.46 0.784
2vie VG0Beta-secretase 1 3.4.23.46 0.781
2vj6 VG5Beta-secretase 1 3.4.23.46 0.780
3nsh 957Beta-secretase 1 3.4.23.46 0.772
4i0i 957Beta-secretase 1 3.4.23.46 0.772
4ewo 996Beta-secretase 1 3.4.23.46 0.770
2wez ZYEBeta-secretase 1 3.4.23.46 0.767
3cid 318Beta-secretase 1 3.4.23.46 0.767
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.765
3dv5 BAVBeta-secretase 1 3.4.23.46 0.765
4dpi 0N1Beta-secretase 1 3.4.23.46 0.762
3lpk Z76Beta-secretase 1 3.4.23.46 0.759
3ohh 3HHBeta-secretase 1 3.4.23.46 0.759
3r2f PB0Beta-secretase 1 3.4.23.46 0.759
4k8s 1QTBeta-secretase 1 3.4.23.46 0.758
1w51 L01Beta-secretase 1 3.4.23.46 0.753
2b8v 3BNBeta-secretase 1 3.4.23.46 0.749
4dpf 0LGBeta-secretase 1 3.4.23.46 0.748
4fco 0U4Beta-secretase 1 3.4.23.46 0.748
3k5g BJCBeta-secretase 1 3.4.23.46 0.747
3ohf 3HFBeta-secretase 1 3.4.23.46 0.744
3cic 316Beta-secretase 1 3.4.23.46 0.737
2hiz LIJBeta-secretase 1 3.4.23.46 0.730
2b8l 5HABeta-secretase 1 3.4.23.46 0.727
2vij C44Beta-secretase 1 3.4.23.46 0.718
2vj9 VG7Beta-secretase 1 3.4.23.46 0.716
3lpi Z74Beta-secretase 1 3.4.23.46 0.713
4dus 0MPBeta-secretase 1 3.4.23.46 0.712
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.710
2qzl IXSBeta-secretase 1 3.4.23.46 0.693
2fdp FRPBeta-secretase 1 3.4.23.46 0.669
3tpr 5HABeta-secretase 1 3.4.23.46 0.666
3k5c 0BIBeta-secretase 1 3.4.23.46 0.663
3dv1 AR9Beta-secretase 1 3.4.23.46 0.659
3n4l 842Beta-secretase 1 3.4.23.46 0.653