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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nu0 3TU Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nu0 3TUDihydrofolate reductase 1.5.1.3 1.140
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.994
3ghv GHCDihydrofolate reductase 1.5.1.3 0.858
3ghw GHWDihydrofolate reductase 1.5.1.3 0.857
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.843
4m6k FOLDihydrofolate reductase 1.5.1.3 0.814
4keb FOLDihydrofolate reductase 1.5.1.3 0.778
4kfj FOLDihydrofolate reductase 1.5.1.3 0.778
2w3m FOLDihydrofolate reductase 1.5.1.3 0.774
1hfp MOTDihydrofolate reductase 1.5.1.3 0.771
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.758
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.755
4x5g FOLDihydrofolate reductase 1.5.1.3 0.752
1drf FOLDihydrofolate reductase 1.5.1.3 0.750
1hfq MOTDihydrofolate reductase 1.5.1.3 0.750
5ccc DDFDihydrofolate reductase 1.5.1.3 0.750
1u70 MTXDihydrofolate reductase 1.5.1.3 0.749
1u72 MTXDihydrofolate reductase 1.5.1.3 0.746
4m6l 21VDihydrofolate reductase 1.5.1.3 0.745
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.740
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.739
3eig MTXDihydrofolate reductase 1.5.1.3 0.737
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.734
4i1n FOLDihydrofolate reductase 1.5.1.3 0.732
4p68 MTXDihydrofolate reductase / 0.732
3dau MTXDihydrofolate reductase 1.5.1.3 0.730
1dyj DDFDihydrofolate reductase 1.5.1.3 0.729
2qk8 MTXDihydrofolate reductase / 0.728
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.727
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.725
1dhf FOLDihydrofolate reductase 1.5.1.3 0.717
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.717
1hfr MOTDihydrofolate reductase 1.5.1.3 0.716
1dls MTXDihydrofolate reductase 1.5.1.3 0.709
4i13 FOLDihydrofolate reductase 1.5.1.3 0.708
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.706
4x5f FOLDihydrofolate reductase 1.5.1.3 0.705
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.704
3tqb FOLDihydrofolate reductase / 0.704
1dre MTXDihydrofolate reductase 1.5.1.3 0.703
1dhj MTXDihydrofolate reductase 1.5.1.3 0.702
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.701
1dyi FOLDihydrofolate reductase 1.5.1.3 0.701
4qi9 MTXDihydrofolate reductase / 0.701
4dfr MTXDihydrofolate reductase 1.5.1.3 0.700
1ohj COPDihydrofolate reductase 1.5.1.3 0.697
1df7 MTXDihydrofolate reductase 1.5.1.3 0.696
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.696
1dra MTXDihydrofolate reductase 1.5.1.3 0.695
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.694
3frd DHFDihydrofolate reductase 1.5.1.3 0.694
3ia4 MTXDihydrofolate reductase / 0.694
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.693
1jol FFODihydrofolate reductase 1.5.1.3 0.692
3och 2MXDihydrofolate reductase 1.5.1.3 0.691
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.690
2zza FOLDihydrofolate reductase / 0.689
5hi6 MTXDihydrofolate reductase / 0.689
7dfr FOLDihydrofolate reductase 1.5.1.3 0.689
1dhi MTXDihydrofolate reductase 1.5.1.3 0.688
2drc MTXDihydrofolate reductase 1.5.1.3 0.688
3dfr MTXDihydrofolate reductase 1.5.1.3 0.681
2d0k FOLDihydrofolate reductase 1.5.1.3 0.679
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.678
2dhf DZFDihydrofolate reductase 1.5.1.3 0.677
4x5i FOLDihydrofolate reductase 1.5.1.3 0.677
1drb MTXDihydrofolate reductase 1.5.1.3 0.676
4x5h FOLDihydrofolate reductase 1.5.1.3 0.676
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.673
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.672
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.671
3tq9 MTXDihydrofolate reductase / 0.671
3drc MTXDihydrofolate reductase 1.5.1.3 0.669
4p66 MTXDihydrofolate reductase / 0.669
2g1m 4HGEgl nine homolog 1 / 0.667
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.666
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.665
1tdr MTXDihydrofolate reductase 1.5.1.3 0.664
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.661
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.660
1ohk COPDihydrofolate reductase 1.5.1.3 0.658
1re7 FOLDihydrofolate reductase 1.5.1.3 0.658
3uwq U5POrotidine 5'-phosphate decarboxylase / 0.657
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.655
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.654
5iot UMPFlavin-dependent thymidylate synthase 2.1.1.148 0.654