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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ntz 3TZ Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ntz 3TZDihydrofolate reductase 1.5.1.3 1.108
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.994
3ghv GHCDihydrofolate reductase 1.5.1.3 0.867
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.861
3ghw GHWDihydrofolate reductase 1.5.1.3 0.857
4m6k FOLDihydrofolate reductase 1.5.1.3 0.829
4kfj FOLDihydrofolate reductase 1.5.1.3 0.804
2w3m FOLDihydrofolate reductase 1.5.1.3 0.785
1drf FOLDihydrofolate reductase 1.5.1.3 0.768
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.750
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.745
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.739
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.739
1dhf FOLDihydrofolate reductase 1.5.1.3 0.737
1u72 MTXDihydrofolate reductase 1.5.1.3 0.737
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.737
4x5g FOLDihydrofolate reductase 1.5.1.3 0.737
3dau MTXDihydrofolate reductase 1.5.1.3 0.736
4i13 FOLDihydrofolate reductase 1.5.1.3 0.734
1hfp MOTDihydrofolate reductase 1.5.1.3 0.732
1hfr MOTDihydrofolate reductase 1.5.1.3 0.732
1dyj DDFDihydrofolate reductase 1.5.1.3 0.731
5hi6 MTXDihydrofolate reductase / 0.731
4x5f FOLDihydrofolate reductase 1.5.1.3 0.730
4m6l 21VDihydrofolate reductase 1.5.1.3 0.729
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.728
4p66 MTXDihydrofolate reductase / 0.728
1df7 MTXDihydrofolate reductase 1.5.1.3 0.727
3dfr MTXDihydrofolate reductase 1.5.1.3 0.724
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.721
1dyi FOLDihydrofolate reductase 1.5.1.3 0.720
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.720
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.720
3eig MTXDihydrofolate reductase 1.5.1.3 0.718
1dyh DZFDihydrofolate reductase 1.5.1.3 0.716
1u70 MTXDihydrofolate reductase 1.5.1.3 0.715
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.714
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.714
2d0k FOLDihydrofolate reductase 1.5.1.3 0.714
2drc MTXDihydrofolate reductase 1.5.1.3 0.714
4dfr MTXDihydrofolate reductase 1.5.1.3 0.713
1dhj MTXDihydrofolate reductase 1.5.1.3 0.712
3drc MTXDihydrofolate reductase 1.5.1.3 0.712
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.712
3och 2MXDihydrofolate reductase 1.5.1.3 0.711
7dfr FOLDihydrofolate reductase 1.5.1.3 0.711
4i1n FOLDihydrofolate reductase 1.5.1.3 0.708
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.707
3tqb FOLDihydrofolate reductase / 0.706
1dls MTXDihydrofolate reductase 1.5.1.3 0.704
1hfq MOTDihydrofolate reductase 1.5.1.3 0.702
3frd DHFDihydrofolate reductase 1.5.1.3 0.699
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.698
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.697
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.697
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.692
1tdr MTXDihydrofolate reductase 1.5.1.3 0.692
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.692
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.692
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.690
1dra MTXDihydrofolate reductase 1.5.1.3 0.684
1dre MTXDihydrofolate reductase 1.5.1.3 0.682
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.681
4x5h FOLDihydrofolate reductase 1.5.1.3 0.679
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.677
3tq9 MTXDihydrofolate reductase / 0.677
4keb FOLDihydrofolate reductase 1.5.1.3 0.677
2zza FOLDihydrofolate reductase / 0.675
4p68 MTXDihydrofolate reductase / 0.675
4kjj FOLDihydrofolate reductase 1.5.1.3 0.674
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.671
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.671
5ccc DDFDihydrofolate reductase 1.5.1.3 0.671
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.664
2dhf DZFDihydrofolate reductase 1.5.1.3 0.664
3zku HCVIsopenicillin N synthase 1.21.3.1 0.664
1e26 GPBDihydrofolate reductase 1.5.1.3 0.662
1uzw CDHIsopenicillin N synthase 1.21.3.1 0.661
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.659
4fhb FOLDihydrofolate reductase 1.5.1.3 0.657
1dhi MTXDihydrofolate reductase 1.5.1.3 0.656
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.656
1re7 FOLDihydrofolate reductase 1.5.1.3 0.655
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.654
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.653