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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lpi Z74 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lpi Z74Beta-secretase 1 3.4.23.46 1.448
3lpk Z76Beta-secretase 1 3.4.23.46 1.306
3cib 314Beta-secretase 1 3.4.23.46 1.264
3cic 316Beta-secretase 1 3.4.23.46 1.155
3cid 318Beta-secretase 1 3.4.23.46 1.105
2iqg F2IBeta-secretase 1 3.4.23.46 1.093
3lpj Z75Beta-secretase 1 3.4.23.46 1.047
2p83 MR0Beta-secretase 1 3.4.23.46 1.000
3qi1 C6ABeta-secretase 1 3.4.23.46 0.866
3ohh 3HHBeta-secretase 1 3.4.23.46 0.864
2p8h MY9Beta-secretase 1 3.4.23.46 0.862
4dpi 0N1Beta-secretase 1 3.4.23.46 0.861
2b8v 3BNBeta-secretase 1 3.4.23.46 0.857
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.851
3ohf 3HFBeta-secretase 1 3.4.23.46 0.850
4dpf 0LGBeta-secretase 1 3.4.23.46 0.842
1w51 L01Beta-secretase 1 3.4.23.46 0.837
4k9h 1QUBeta-secretase 1 3.4.23.46 0.813
4d89 BXDBeta-secretase 1 3.4.23.46 0.810
2b8l 5HABeta-secretase 1 3.4.23.46 0.808
3qbh QBHBeta-secretase 1 3.4.23.46 0.806
3nsh 957Beta-secretase 1 3.4.23.46 0.801
4i0i 957Beta-secretase 1 3.4.23.46 0.801
3vf3 0GSBeta-secretase 1 3.4.23.46 0.797
3vg1 0GTBeta-secretase 1 3.4.23.46 0.795
2vj9 VG7Beta-secretase 1 3.4.23.46 0.793
3i25 MV7Beta-secretase 1 3.4.23.46 0.791
3dv5 BAVBeta-secretase 1 3.4.23.46 0.789
4lxm 1YUBeta-secretase 1 3.4.23.46 0.789
4fco 0U4Beta-secretase 1 3.4.23.46 0.786
3k5g BJCBeta-secretase 1 3.4.23.46 0.784
3k5c 0BIBeta-secretase 1 3.4.23.46 0.778
4ewo 996Beta-secretase 1 3.4.23.46 0.776
2vnn CM7Beta-secretase 1 3.4.23.46 0.771
2vie VG0Beta-secretase 1 3.4.23.46 0.767
2xfi XFIBeta-secretase 1 3.4.23.46 0.767
2vij C44Beta-secretase 1 3.4.23.46 0.766
3ixj 586Beta-secretase 1 3.4.23.46 0.765
4exg 916Beta-secretase 1 3.4.23.46 0.764
2qzl IXSBeta-secretase 1 3.4.23.46 0.745
3ixk 929Beta-secretase 1 3.4.23.46 0.745
4dus 0MPBeta-secretase 1 3.4.23.46 0.740
3veu 0GOBeta-secretase 1 3.4.23.46 0.731
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.726
2xfk AA9Beta-secretase 1 3.4.23.46 0.726
3r2f PB0Beta-secretase 1 3.4.23.46 0.721
3dm6 757Beta-secretase 1 3.4.23.46 0.720
3k5f AYHBeta-secretase 1 3.4.23.46 0.715
3tpr 5HABeta-secretase 1 3.4.23.46 0.715
3pi5 3P5Beta-secretase 1 3.4.23.46 0.713
4ke0 1R8Beta-secretase 1 3.4.23.46 0.710
4k8s 1QTBeta-secretase 1 3.4.23.46 0.708
4i0h 1BLBeta-secretase 1 3.4.23.46 0.703
2f3e AXQBeta-secretase 1 3.4.23.46 0.702
4ke1 1R6Beta-secretase 1 3.4.23.46 0.701
4lxk 1YTBeta-secretase 1 3.4.23.46 0.701
2vj7 VG6Beta-secretase 1 3.4.23.46 0.700
2p4j 23IBeta-secretase 1 3.4.23.46 0.698
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.698
2wez ZYEBeta-secretase 1 3.4.23.46 0.696
2viz VG4Beta-secretase 1 3.4.23.46 0.695
2hm1 LIQBeta-secretase 1 3.4.23.46 0.694
3duy AFJBeta-secretase 1 3.4.23.46 0.692
1xe6 5FPPlasmepsin-2 3.4.23.39 0.691
4gid 0GHBeta-secretase 1 3.4.23.46 0.689
2f3f AXFBeta-secretase 1 3.4.23.46 0.686
2vj6 VG5Beta-secretase 1 3.4.23.46 0.686
3skg PB8Beta-secretase 1 3.4.23.46 0.685
2vkm BSDBeta-secretase 1 3.4.23.46 0.683
3n4l 842Beta-secretase 1 3.4.23.46 0.682
2xfj VG5Beta-secretase 1 3.4.23.46 0.678
2vnm CM8Beta-secretase 1 3.4.23.46 0.675
2viy VG3Beta-secretase 1 3.4.23.46 0.674
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.674
2hiz LIJBeta-secretase 1 3.4.23.46 0.673
1psa 0ZLPepsin A 3.4.23.1 0.672
2fdp FRPBeta-secretase 1 3.4.23.46 0.671
4lxa 1YSBeta-secretase 1 3.4.23.46 0.671
2g94 ZPQBeta-secretase 1 3.4.23.46 0.668
2ntr L00Beta-secretase 1 3.4.23.46 0.665
3dv1 AR9Beta-secretase 1 3.4.23.46 0.665
2jji 0QSEndothiapepsin 3.4.23.22 0.661
3k5d XLIBeta-secretase 1 3.4.23.46 0.660
2oah QINBeta-secretase 1 3.4.23.46 0.650