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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lfb Z87 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lfb Z87Mitogen-activated protein kinase 14 / 0.977
3lfe Z84Mitogen-activated protein kinase 14 / 0.865
3lff Z83Mitogen-activated protein kinase 14 / 0.856
3pg3 DG7Mitogen-activated protein kinase 14 / 0.830
3hv6 R39Mitogen-activated protein kinase 14 / 0.803
3hv3 R49Mitogen-activated protein kinase 14 / 0.791
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.784
2puu G2GMitogen-activated protein kinase 14 / 0.778
2yiw YIWMitogen-activated protein kinase 14 / 0.776
3gcq 1BUMitogen-activated protein kinase 14 / 0.772
3hv5 R24Mitogen-activated protein kinase 14 / 0.771
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.767
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.763
2yis YISMitogen-activated protein kinase 14 / 0.759
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.748
1w82 L10Mitogen-activated protein kinase 14 / 0.746
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3gcu R48Mitogen-activated protein kinase 14 / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.731
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.723
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.719
3p5k P5KMitogen-activated protein kinase 14 / 0.714
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.707
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.706
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.704
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.699
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.697
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.694
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.689
1kv2 B96Mitogen-activated protein kinase 14 / 0.688
3uvr 06FMitogen-activated protein kinase 14 / 0.683
1kv1 BMUMitogen-activated protein kinase 14 / 0.681
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.680
3gcv SS6Mitogen-activated protein kinase 14 / 0.680
3gcs BAXMitogen-activated protein kinase 14 / 0.675
3o8u BMUMitogen-activated protein kinase 14 / 0.672
3p7c P7CMitogen-activated protein kinase 14 / 0.668
3o8t BMUMitogen-activated protein kinase 14 / 0.663