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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lfa 1N1 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lfa 1N1Mitogen-activated protein kinase 14 / 1.021
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.845
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.821
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.811
4kiq 1RAMitogen-activated protein kinase 14 / 0.795
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.788
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.788
4kin 1M8Mitogen-activated protein kinase 14 / 0.782
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.769
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.769
3gfe P37Mitogen-activated protein kinase 14 / 0.760
3ocg OCGMitogen-activated protein kinase 14 / 0.754
4eh6 0ONMitogen-activated protein kinase 14 / 0.751
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3fkl FKLMitogen-activated protein kinase 14 / 0.707
2zm1 KSFTyrosine-protein kinase Lck 2.7.10.2 0.705
3l8x N4DMitogen-activated protein kinase 14 / 0.704
3iph G11Mitogen-activated protein kinase 14 / 0.703
3fsk RO6Mitogen-activated protein kinase 14 / 0.701
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.696
3mvm 39PMitogen-activated protein kinase 14 / 0.696
2zb0 GK3Mitogen-activated protein kinase 14 / 0.691
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.676
4aa5 NQBMitogen-activated protein kinase 14 / 0.674
3e92 G6AMitogen-activated protein kinase 14 / 0.673
4nk9 2K5Fibroblast growth factor receptor 1 / 0.672
3bx5 304Mitogen-activated protein kinase 14 / 0.670
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.669
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.661
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4kip 1R9Mitogen-activated protein kinase 14 / 0.660
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.657
3uvp 048Mitogen-activated protein kinase 14 / 0.656
3w5q 3KLVitamin D3 receptor / 0.655
3cem AVDGlycogen phosphorylase, liver form 2.4.1.1 0.650