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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ju8 NAD N-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 1.101
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.793
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.787
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.782
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.778
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.770
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.768
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.763
4i8q NADPutative betaine aldehyde dehyrogenase / 0.761
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.756
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.754
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.740
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.734
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.734
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.730
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.720
2jg7 NADAntiquitin / 0.719
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.715
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.703
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.699
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.691
3b4w NADAldehyde dehydrogenase family protein / 0.690
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.690
3haz NADBifunctional protein PutA / 0.688
4i8p NADAminoaldehyde dehydrogenase 1 / 0.682
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.680
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.679
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.676
4pz2 NADAldehyde dehydrogenase 2-6 / 0.675
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.668
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.666
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.665
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.652
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.652
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.650