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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ia4 MTX Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ia4 MTXDihydrofolate reductase / 1.165
2drc MTXDihydrofolate reductase 1.5.1.3 0.965
3och 2MXDihydrofolate reductase 1.5.1.3 0.929
2qk8 MTXDihydrofolate reductase / 0.907
4dfr MTXDihydrofolate reductase 1.5.1.3 0.907
3dau MTXDihydrofolate reductase 1.5.1.3 0.904
3tq9 MTXDihydrofolate reductase / 0.902
3drc MTXDihydrofolate reductase 1.5.1.3 0.900
5hi6 MTXDihydrofolate reductase / 0.899
1df7 MTXDihydrofolate reductase 1.5.1.3 0.867
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.867
1dls MTXDihydrofolate reductase 1.5.1.3 0.866
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.857
1dra MTXDihydrofolate reductase 1.5.1.3 0.847
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.846
1dhj MTXDihydrofolate reductase 1.5.1.3 0.845
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.840
1u70 MTXDihydrofolate reductase 1.5.1.3 0.838
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.838
1dre MTXDihydrofolate reductase 1.5.1.3 0.834
3dat MTXDihydrofolate reductase / 0.832
3eig MTXDihydrofolate reductase 1.5.1.3 0.821
3dfr MTXDihydrofolate reductase 1.5.1.3 0.818
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.800
4p66 MTXDihydrofolate reductase / 0.799
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.781
1e26 GPBDihydrofolate reductase 1.5.1.3 0.778
4p68 MTXDihydrofolate reductase / 0.776
3frd DHFDihydrofolate reductase 1.5.1.3 0.775
4qi9 MTXDihydrofolate reductase / 0.774
1u72 MTXDihydrofolate reductase 1.5.1.3 0.768
1hfr MOTDihydrofolate reductase 1.5.1.3 0.766
2zza FOLDihydrofolate reductase / 0.751
4i1n FOLDihydrofolate reductase 1.5.1.3 0.748
1drf FOLDihydrofolate reductase 1.5.1.3 0.746
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.740
1dhi MTXDihydrofolate reductase 1.5.1.3 0.736
1hfp MOTDihydrofolate reductase 1.5.1.3 0.731
1dhf FOLDihydrofolate reductase 1.5.1.3 0.729
4ixg IXGDihydrofolate reductase 1.5.1.3 0.727
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.724
1tdr MTXDihydrofolate reductase 1.5.1.3 0.720
1jom FFODihydrofolate reductase 1.5.1.3 0.718
4i13 FOLDihydrofolate reductase 1.5.1.3 0.715
4x5i FOLDihydrofolate reductase 1.5.1.3 0.714
2d0k FOLDihydrofolate reductase 1.5.1.3 0.713
4kfj FOLDihydrofolate reductase 1.5.1.3 0.710
2w3m FOLDihydrofolate reductase 1.5.1.3 0.708
1hfq MOTDihydrofolate reductase 1.5.1.3 0.706
4keb FOLDihydrofolate reductase 1.5.1.3 0.706
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.704
4kjj FOLDihydrofolate reductase 1.5.1.3 0.701
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.700
4x5g FOLDihydrofolate reductase 1.5.1.3 0.699
1dds MTXDihydrofolate reductase 1.5.1.3 0.697
2dhf DZFDihydrofolate reductase 1.5.1.3 0.697
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.694
5ccc DDFDihydrofolate reductase 1.5.1.3 0.694
3td8 D2RDihydrofolate reductase 1.5.1.3 0.692
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.691
1ddr MTXDihydrofolate reductase 1.5.1.3 0.688
4x5h FOLDihydrofolate reductase 1.5.1.3 0.688
4m6l 21VDihydrofolate reductase 1.5.1.3 0.686
1drb MTXDihydrofolate reductase 1.5.1.3 0.685
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.685
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.683
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.678
3tqb FOLDihydrofolate reductase / 0.678
4m6k FOLDihydrofolate reductase 1.5.1.3 0.677
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.676
1dyi FOLDihydrofolate reductase 1.5.1.3 0.673
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.671
4gkm 683Anthranilate phosphoribosyltransferase / 0.668
3ghv GHCDihydrofolate reductase 1.5.1.3 0.665
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.664
7dfr FOLDihydrofolate reductase 1.5.1.3 0.663
1ohj COPDihydrofolate reductase 1.5.1.3 0.662
4elf 35IDihydrofolate reductase / 0.662
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.661
3fl8 RARDihydrofolate reductase / 0.659
1dyj DDFDihydrofolate reductase 1.5.1.3 0.658
1kms LIHDihydrofolate reductase 1.5.1.3 0.658
1mvt DTMDihydrofolate reductase 1.5.1.3 0.654
4x5f FOLDihydrofolate reductase 1.5.1.3 0.654
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.653
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.650
3jwm 5WBDihydrofolate reductase / 0.650
3s7a 684Dihydrofolate reductase 1.5.1.3 0.650