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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3i5z Z48 Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 1.055
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.939
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.868
4fv5 EK9Mitogen-activated protein kinase 1 2.7.11.24 0.834
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.767
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.722
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.711
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.699
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.694
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.694
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.683
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.676
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.666
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.663
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.662
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.660
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.654
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.654
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.654
3uo5 0BXAurora kinase A 2.7.11.1 0.652
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.650