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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3h2s NDP Putative NADH-flavin reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3h2s NDPPutative NADH-flavin reductase / 1.376
4oqy NDP(S)-imine reductase / 0.749
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.748
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.724
1hdo NAPFlavin reductase (NADPH) / 0.700
2hk9 NAPShikimate dehydrogenase (NADP(+)) / 0.696
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.695
1xq6 NAPUncharacterized protein At5g02240 / 0.694
1x7g NAPPutative ketoacyl reductase 1.3.1 0.693
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.693
2c20 NADUDP-glucose 4-epimerase / 0.686
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.685
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.681
3e8x NAPBH1520 protein / 0.681
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.678
4z0p NDPNAD-dependent dehydrogenase / 0.678
2wdz NADGalactitol dehydrogenase / 0.676
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.676
2yut NAPPutative short-chain oxidoreductase / 0.673
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.673
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.671
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.670
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.670
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.670
4hwk NAPSepiapterin reductase 1.1.1.153 0.670
4euf NADTrans-2-enoyl-CoA reductase [NADH] / 0.669
5a03 NDPGlucose-fructose oxidoreductase / 0.668
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.667
5a02 NAPGlucose-fructose oxidoreductase / 0.667
5a05 NDPGlucose-fructose oxidoreductase / 0.667
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.666
3gwf NAPCyclohexanone monooxygenase / 0.666
1g1a NADdTDP-glucose 4,6-dehydratase / 0.664
1oaa NAPSepiapterin reductase 1.1.1.153 0.664
1pjc NADAlanine dehydrogenase / 0.663
1ae1 NAPTropinone reductase 1 / 0.662
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.662
4hnh NAPNAD-dependent epimerase/dehydratase / 0.662
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.661
1pr9 NAPL-xylulose reductase 1.1.1.10 0.660
2jl1 NAPTriphenylmethane reductase / 0.660
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.659
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.659
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.658
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.657
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.657
2iyp A2P6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.656
2yy7 NADL-threonine dehydrogenase / 0.654
4bmv NAPShort-chain dehydrogenase / 0.654
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.654
3ean NAPThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.653
3p19 NDPPutative blue fluorescent protein / 0.653
4j7u NAPSepiapterin reductase 1.1.1.153 0.653
4rcv NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.653
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.652
4kwh NAPReductase homolog / 0.652
1x7h NDPPutative ketoacyl reductase 1.3.1 0.651
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.651
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.650
5a04 NDPGlucose-fructose oxidoreductase / 0.650