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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gu3 SAH Methyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gu3 SAHMethyltransferase / 0.863
3p9k SAHCaffeic acid O-methyltransferase / 0.722
4qtu SAM18S rRNA (guanine(1575)-N(7))-methyltransferase / 0.714
4a6d SAMAcetylserotonin O-methyltransferase 2.1.1.4 0.702
4iwn GEKCarboxy-S-adenosyl-L-methionine synthase / 0.700
3dmg SAHProbable ribosomal RNA small subunit methyltransferase / 0.699
3lst SAHCalO1 / 0.694
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.690
3iei SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.689
2p35 SAHTrans-aconitate 2-methyltransferase / 0.682
3dmh SAMProbable ribosomal RNA small subunit methyltransferase / 0.682
3ou2 SAHSAM-dependent methyltransferase / 0.682
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.678
4gek GEKCarboxy-S-adenosyl-L-methionine synthase / 0.677
3e8s SAHUncharacterized protein / 0.675
1f3l SAHProtein arginine N-methyltransferase 3 / 0.674
1qzz SAMAclacinomycin 10-hydroxylase RdmB 4.1.1 0.671
2y1w SFGHistone-arginine methyltransferase CARM1 / 0.670
1kr5 SAHProtein-L-isoaspartate(D-aspartate) O-methyltransferase 2.1.1.77 0.669
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.669
2xvm SAHTellurite methyltransferase 2.1.1.265 0.669
5f8f SFGPossible transcriptional regulatory protein / 0.669
1ri3 SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.668
3p2e SAH16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.667
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.665
4c04 SFGProtein arginine N-methyltransferase 6 / 0.664
4c03 SFGProtein arginine N-methyltransferase 6 / 0.663
2yqz SAMUncharacterized protein / 0.661
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.661
5dxj SFGHistone-arginine methyltransferase CARM1 / 0.660
3dlc SAMSAM (And some other nucleotide) binding motif:Generic methyltransferase / 0.659
3ou7 SAMSAM-dependent methyltransferase / 0.659
2y1x SAHHistone-arginine methyltransferase CARM1 / 0.658
3b3f SAHHistone-arginine methyltransferase CARM1 / 0.657
5dx8 SFGHistone-arginine methyltransferase CARM1 / 0.657
4iv0 SAMPhosphoethanolamine N-methyltransferase, putative / 0.656
2zwa SAHtRNA wybutosine-synthesizing protein 4 2.1.1.290 0.655
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.655
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.652
4hh4 SAHCcbJ / 0.652
5dx1 SFGHistone-arginine methyltransferase CARM1 / 0.652
3o7w SAMLeucine carboxyl methyltransferase 1 2.1.1.233 0.651
4rdi ATPtRNA threonylcarbamoyladenosine dehydratase 6.1 0.651
3bgv SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.650
3pb3 SAH16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.650