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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gkj HC3 Niemann-Pick C1 protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gkj HC3Niemann-Pick C1 protein / 1.332
3gki CLRNiemann-Pick C1 protein / 1.099
2aa6 STRMineralocorticoid receptor / 0.722
4e5l DBHPolymerase acidic protein / 0.720
3up3 XCAaceDAF-12 / 0.715
1gwr ESTEstrogen receptor / 0.713
1kdm DHTSex hormone-binding globulin / 0.707
1tw4 CHDFatty acid-binding protein, liver / 0.703
4a81 DXCMajor pollen allergen Bet v 1-A / 0.700
2aa5 STRMineralocorticoid receptor / 0.696
4j26 ESTEstrogen receptor beta / 0.696
1n83 CLRNuclear receptor ROR-alpha / 0.695
1ya3 STRMineralocorticoid receptor / 0.695
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.688
3s79 ASDAromatase 1.14.14.14 0.687
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.678
4c49 HCYCorticosteroid-binding globulin / 0.672
1zhz ERGOxysterol-binding protein homolog 4 / 0.667
2azz TCHPhospholipase A2, major isoenzyme 3.1.1.4 0.667
4e5f 0N7Polymerase acidic protein / 0.664
3ruk AERSteroid 17-alpha-hydroxylase/17,20 lyase / 0.663
2aib ERGBeta-elicitin cinnamomin / 0.662
2hzq STRApolipoprotein D / 0.660
3oll ESTEstrogen receptor beta / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4qe6 JN3Bile acid receptor / 0.660
1ot7 CHCBile acid receptor / 0.658
5xra CLRCannabinoid receptor 1 / 0.658
3kxw 1ZZSaframycin Mx1 synthetase B / 0.657
4c2z MYAGlycylpeptide N-tetradecanoyltransferase 1 / 0.656
3dl9 V2HVitamin D 25-hydroxylase / 0.650
4c2y MYAGlycylpeptide N-tetradecanoyltransferase 1 / 0.650