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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ghs LDT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ghs LDTAldose reductase 1.1.1.21 1.123
3ghr LDTAldose reductase 1.1.1.21 1.121
2i17 LDTAldose reductase 1.1.1.21 1.102
1us0 LDTAldose reductase 1.1.1.21 1.101
2i16 LDTAldose reductase 1.1.1.21 1.101
2qxw LDTAldose reductase 1.1.1.21 1.099
3lbo LDTAldose reductase 1.1.1.21 1.080
3ght LDTAldose reductase 1.1.1.21 1.068
3ghu LDTAldose reductase 1.1.1.21 1.066
3lz5 LDTAldose reductase 1.1.1.21 1.062
3ld5 LDTAldose reductase 1.1.1.21 1.059
3lql LDTAldose reductase 1.1.1.21 1.037
3m4h 388Aldose reductase 1.1.1.21 0.975
2iki 388Aldose reductase 1.1.1.21 0.912
2ikj 393Aldose reductase 1.1.1.21 0.856
3m64 393Aldose reductase 1.1.1.21 0.854
2pdc 393Aldose reductase 1.1.1.21 0.820
2pzn 393Aldose reductase 1.1.1.21 0.816
3mc5 393Aldose reductase 1.1.1.21 0.811
2pdj 393Aldose reductase 1.1.1.21 0.810
3t42 3T4Aldose reductase 1.1.1.21 0.798
2pdi ZSTAldose reductase 1.1.1.21 0.796
2fz8 ZSTAldose reductase 1.1.1.21 0.775
2pdp 393Aldose reductase 1.1.1.21 0.771
2pdu 393Aldose reductase 1.1.1.21 0.737
1t40 ID5Aldose reductase 1.1.1.21 0.731
1iei ZESAldose reductase 1.1.1.21 0.716
2pdq 47DAldose reductase 1.1.1.21 0.711
4gca 2X9Aldose reductase 1.1.1.21 0.696
2inz OHPAldose reductase 1.1.1.21 0.692
2hvo ZSTAldose reductase 1.1.1.21 0.686
2pdn 47DAldose reductase 1.1.1.21 0.684
2dv0 ZSTAldose reductase 1.1.1.21 0.683
3s3g TLTAldose reductase 1.1.1.21 0.682
2fz9 ZSTAldose reductase 1.1.1.21 0.678
2fzd TOLAldose reductase 1.1.1.21 0.678
1frb ZSTAldose reductase-related protein 2 / 0.676
4yu1 53NAldose reductase 1.1.1.21 0.675
2nvc ITAAldose reductase 1.1.1.21 0.674
2pdh 47DAldose reductase 1.1.1.21 0.671
3m0i ZSTAldose reductase 1.1.1.21 0.671
2iqd LPAAldose reductase 1.1.1.21 0.669
1z89 62PAldose reductase 1.1.1.21 0.660
2pdx ZSTAldose reductase 1.1.1.21 0.658
2pdf ZSTAldose reductase 1.1.1.21 0.656
2pdl TOLAldose reductase 1.1.1.21 0.656
2hv5 ZSTAldose reductase 1.1.1.21 0.654
3g5e Q74Aldose reductase 1.1.1.21 0.652
2ipw 2CLAldose reductase 1.1.1.21 0.651