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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3g0f B49 Mast/stem cell growth factor receptor Kit 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.930
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.844
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.727
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.714
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.693
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.693
2jav 5Z5Serine/threonine-protein kinase Nek2 2.7.11.1 0.678
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.677
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.668
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.667
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.663
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.663
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.661
2bfy H1NAurora kinase B-A 2.7.11.1 0.661
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.660
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.656
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.656
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.651
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.651
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.650