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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fzs B96 Protein-tyrosine kinase 2-beta 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 1.361
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.911
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.863
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.820
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3hv5 R24Mitogen-activated protein kinase 14 / 0.704
3uvr 06FMitogen-activated protein kinase 14 / 0.700
2puu G2GMitogen-activated protein kinase 14 / 0.693
3hv6 R39Mitogen-activated protein kinase 14 / 0.693
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.687
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.685
3gcu R48Mitogen-activated protein kinase 14 / 0.684
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.684
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.684
3lfe Z84Mitogen-activated protein kinase 14 / 0.681
3lfb Z87Mitogen-activated protein kinase 14 / 0.680
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.677
3hv4 L51Mitogen-activated protein kinase 14 / 0.676
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.672
3o8u BMUMitogen-activated protein kinase 14 / 0.670
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.669
3q9w EMOCasein kinase II subunit alpha 2.7.11.1 0.668
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.667
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.667
2yiw YIWMitogen-activated protein kinase 14 / 0.665
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.664
1kv2 B96Mitogen-activated protein kinase 14 / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3pg3 DG7Mitogen-activated protein kinase 14 / 0.658
3w2s W2REpidermal growth factor receptor 2.7.10.1 0.656
3c13 EMOCasein kinase II subunit alpha 2.7.11.1 0.654
4eh7 0OOMitogen-activated protein kinase 14 / 0.653
2foi JPAEnoyl-acyl carrier reductase / 0.652
4app N53Serine/threonine-protein kinase PAK 4 2.7.11.1 0.652
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.652