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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ezr EZR Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 1.061
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.883
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.758
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.756
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.725
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.724
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.724
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.724
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.722
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.712
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.711
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.710
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.705
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.701
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.700
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.700
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.699
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.694
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.692
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.687
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.687
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.686
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.685
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.684
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.683
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.676
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.670
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.670
4ftm 1HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.669
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.667
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.666
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.666
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.662
4nks 2M2Fibroblast growth factor receptor 1 / 0.660
2r3q 5SCCyclin-dependent kinase 2 2.7.11.22 0.659
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.658
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.658
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.658
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.658
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.656
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.655
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.654
2w17 I19Cyclin-dependent kinase 2 2.7.11.22 0.654
2r3p 3SCCyclin-dependent kinase 2 2.7.11.22 0.653
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.653
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.652
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.651