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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eig MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3eig MTXDihydrofolate reductase 1.5.1.3 1.108
4qi9 MTXDihydrofolate reductase / 0.884
4dfr MTXDihydrofolate reductase 1.5.1.3 0.867
1u70 MTXDihydrofolate reductase 1.5.1.3 0.863
3dau MTXDihydrofolate reductase 1.5.1.3 0.857
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.856
3dfr MTXDihydrofolate reductase 1.5.1.3 0.854
3drc MTXDihydrofolate reductase 1.5.1.3 0.852
5hi6 MTXDihydrofolate reductase / 0.852
1dls MTXDihydrofolate reductase 1.5.1.3 0.849
3och 2MXDihydrofolate reductase 1.5.1.3 0.843
1u72 MTXDihydrofolate reductase 1.5.1.3 0.840
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.838
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.830
1dre MTXDihydrofolate reductase 1.5.1.3 0.829
1hfq MOTDihydrofolate reductase 1.5.1.3 0.828
3ia4 MTXDihydrofolate reductase / 0.821
1ohj COPDihydrofolate reductase 1.5.1.3 0.814
4keb FOLDihydrofolate reductase 1.5.1.3 0.813
2drc MTXDihydrofolate reductase 1.5.1.3 0.810
1hfp MOTDihydrofolate reductase 1.5.1.3 0.809
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.807
1hfr MOTDihydrofolate reductase 1.5.1.3 0.804
4m6k FOLDihydrofolate reductase 1.5.1.3 0.799
1df7 MTXDihydrofolate reductase 1.5.1.3 0.798
1drb MTXDihydrofolate reductase 1.5.1.3 0.794
1dhj MTXDihydrofolate reductase 1.5.1.3 0.786
4p66 MTXDihydrofolate reductase / 0.786
2w3m FOLDihydrofolate reductase 1.5.1.3 0.785
1dra MTXDihydrofolate reductase 1.5.1.3 0.783
3dat MTXDihydrofolate reductase / 0.782
1tdr MTXDihydrofolate reductase 1.5.1.3 0.775
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.770
4p68 MTXDihydrofolate reductase / 0.767
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.766
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.764
3tq9 MTXDihydrofolate reductase / 0.763
1dhf FOLDihydrofolate reductase 1.5.1.3 0.758
3ghw GHWDihydrofolate reductase 1.5.1.3 0.754
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.753
4x5f FOLDihydrofolate reductase 1.5.1.3 0.753
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.752
4kfj FOLDihydrofolate reductase 1.5.1.3 0.752
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.750
1drf FOLDihydrofolate reductase 1.5.1.3 0.748
3tqb FOLDihydrofolate reductase / 0.747
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.737
4m6l 21VDihydrofolate reductase 1.5.1.3 0.737
1dhi MTXDihydrofolate reductase 1.5.1.3 0.736
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.736
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.733
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.731
4x5i FOLDihydrofolate reductase 1.5.1.3 0.730
2d0k FOLDihydrofolate reductase 1.5.1.3 0.729
2dhf DZFDihydrofolate reductase 1.5.1.3 0.729
4x5h FOLDihydrofolate reductase 1.5.1.3 0.729
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.728
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.727
4x5g FOLDihydrofolate reductase 1.5.1.3 0.727
1dyj DDFDihydrofolate reductase 1.5.1.3 0.723
1ohk COPDihydrofolate reductase 1.5.1.3 0.723
4i1n FOLDihydrofolate reductase 1.5.1.3 0.723
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.718
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.717
1jom FFODihydrofolate reductase 1.5.1.3 0.716
4i13 FOLDihydrofolate reductase 1.5.1.3 0.714
1e26 GPBDihydrofolate reductase 1.5.1.3 0.713
4kjj FOLDihydrofolate reductase 1.5.1.3 0.713
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.710
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.708
4fhb FOLDihydrofolate reductase 1.5.1.3 0.706
1dyh DZFDihydrofolate reductase 1.5.1.3 0.703
2qk8 MTXDihydrofolate reductase / 0.703
1dds MTXDihydrofolate reductase 1.5.1.3 0.701
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.699
1dyi FOLDihydrofolate reductase 1.5.1.3 0.697
3frd DHFDihydrofolate reductase 1.5.1.3 0.697
5ccc DDFDihydrofolate reductase 1.5.1.3 0.695
1boz PRDDihydrofolate reductase 1.5.1.3 0.694
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.691
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.687
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.685
1kmv LIIDihydrofolate reductase 1.5.1.3 0.677
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.677
2zza FOLDihydrofolate reductase / 0.676
1jol FFODihydrofolate reductase 1.5.1.3 0.675
1njs KEUTrifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.669
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.669
4ixg IXGDihydrofolate reductase 1.5.1.3 0.668
1daj MOTDihydrofolate reductase 1.5.1.3 0.667
3ghv GHCDihydrofolate reductase 1.5.1.3 0.662
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
7dfr FOLDihydrofolate reductase 1.5.1.3 0.659
1u71 MXADihydrofolate reductase 1.5.1.3 0.658
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.655
1s3u TQDDihydrofolate reductase 1.5.1.3 0.653
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.653