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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3e5a VX6 Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3e5a VX6Aurora kinase A 2.7.11.1 1.074
4jbq VX6Aurora kinase A 2.7.11.1 0.868
4b8m VX6Aurora kinase B-A 2.7.11.1 0.832
4af3 VX6Aurora kinase B 2.7.11.1 0.787
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3w16 P9JAurora kinase A 2.7.11.1 0.703
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.690
4f63 0S7Fibroblast growth factor receptor 1 / 0.680
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.679
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.679
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.673
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.669
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.668
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.665
2x81 ZZLAurora kinase A 2.7.11.1 0.662
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.661
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2bmc MPYAurora kinase A 2.7.11.1 0.653
4nks 2M2Fibroblast growth factor receptor 1 / 0.650