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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dtc VIN Mitogen-activated protein kinase kinase kinase 9 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 1.140
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.756
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.754
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.722
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.681
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
3c4e C4ESerine/threonine-protein kinase pim-1 2.7.11.1 0.667
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.656
4nka 2K7Fibroblast growth factor receptor 1 / 0.656
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
3s79 ASDAromatase 1.14.14.14 0.650