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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dog NNN Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dog NNNCyclin-dependent kinase 2 2.7.11.22 0.989
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.837
3ddq RRCCyclin-dependent kinase 2 2.7.11.22 0.791
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.789
3ddp RC8Cyclin-dependent kinase 2 2.7.11.22 0.786
1unl RRCCyclin-dependent-like kinase 5 2.7.11.1 0.768
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.766
2a4l RRCCyclin-dependent kinase 2 2.7.11.22 0.755
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.738
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.737
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.716
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.707
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.703
2btr U73Cyclin-dependent kinase 2 2.7.11.22 0.698
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.687
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.685
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.680
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.678
2r3q 5SCCyclin-dependent kinase 2 2.7.11.22 0.677
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.664
2cdz 23DSerine/threonine-protein kinase PAK 4 2.7.11.1 0.663
2r3o 2SCCyclin-dependent kinase 2 2.7.11.22 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4kd1 1QKCyclin-dependent kinase 2 2.7.11.22 0.660
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.656
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.654
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.652