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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3d84 NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3d84 NDPDihydrofolate reductase 1.5.1.3 1.188
8dfr NDPDihydrofolate reductase 1.5.1.3 0.959
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.945
3nxx NDPDihydrofolate reductase 1.5.1.3 0.942
2w3b NDPDihydrofolate reductase 1.5.1.3 0.931
3tqa NDPDihydrofolate reductase / 0.910
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.895
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.880
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.872
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.855
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.839
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.836
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.821
2cig 1DGDihydrofolate reductase 1.5.1.3 0.815
1m78 NDPDihydrofolate reductase 1.5.1.3 0.786
4m6j NDPDihydrofolate reductase 1.5.1.3 0.775
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.768
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.749
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.739
5ecc NAPDehydrofolate reductase type I / 0.719
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.714
1juv NDPDihydrofolate reductase 1.5.1.3 0.706
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.697
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.695
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.685
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.684
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.665
1drh NAPDihydrofolate reductase 1.5.1.3 0.660
3qlr NDPDihydrofolate reductase 1.5.1.3 0.650