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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ama SKE cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.949
4e5i 0N9Polymerase acidic protein / 0.744
5dr9 SKEAurora kinase A 2.7.11.1 0.712
5dpv SKEAurora kinase A 2.7.11.1 0.702
5dr6 SKEAurora kinase A 2.7.11.1 0.697
5dt0 SKEAurora kinase A 2.7.11.1 0.696
4qmu SKESerine/threonine-protein kinase 24 2.7.11.1 0.683
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.681
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.679
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.677
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.665
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.659
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.658
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650