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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zza FOL Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zza FOLDihydrofolate reductase / 1.048
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.914
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.895
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.874
1dyh DZFDihydrofolate reductase 1.5.1.3 0.868
4x5g FOLDihydrofolate reductase 1.5.1.3 0.861
2drc MTXDihydrofolate reductase 1.5.1.3 0.850
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.847
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.845
1dls MTXDihydrofolate reductase 1.5.1.3 0.838
3dau MTXDihydrofolate reductase 1.5.1.3 0.830
1dra MTXDihydrofolate reductase 1.5.1.3 0.825
4i1n FOLDihydrofolate reductase 1.5.1.3 0.823
1drf FOLDihydrofolate reductase 1.5.1.3 0.820
4dfr MTXDihydrofolate reductase 1.5.1.3 0.819
4m6k FOLDihydrofolate reductase 1.5.1.3 0.819
1dyi FOLDihydrofolate reductase 1.5.1.3 0.818
3tqb FOLDihydrofolate reductase / 0.816
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.812
4x5f FOLDihydrofolate reductase 1.5.1.3 0.812
4x5h FOLDihydrofolate reductase 1.5.1.3 0.805
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.802
4kjj FOLDihydrofolate reductase 1.5.1.3 0.801
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.800
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.800
3och 2MXDihydrofolate reductase 1.5.1.3 0.800
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.796
4kfj FOLDihydrofolate reductase 1.5.1.3 0.791
1ohj COPDihydrofolate reductase 1.5.1.3 0.787
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.787
1dre MTXDihydrofolate reductase 1.5.1.3 0.786
3drc MTXDihydrofolate reductase 1.5.1.3 0.785
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.784
1dhj MTXDihydrofolate reductase 1.5.1.3 0.783
3tq9 MTXDihydrofolate reductase / 0.783
4i13 FOLDihydrofolate reductase 1.5.1.3 0.783
4fhb FOLDihydrofolate reductase 1.5.1.3 0.782
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.777
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.777
1hfr MOTDihydrofolate reductase 1.5.1.3 0.776
1tdr MTXDihydrofolate reductase 1.5.1.3 0.775
7dfr FOLDihydrofolate reductase 1.5.1.3 0.771
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.769
2qk8 MTXDihydrofolate reductase / 0.765
4p66 MTXDihydrofolate reductase / 0.764
3frd DHFDihydrofolate reductase 1.5.1.3 0.760
4x5i FOLDihydrofolate reductase 1.5.1.3 0.759
5hi6 MTXDihydrofolate reductase / 0.758
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.756
1hfp MOTDihydrofolate reductase 1.5.1.3 0.754
3ia4 MTXDihydrofolate reductase / 0.751
1jol FFODihydrofolate reductase 1.5.1.3 0.747
1jom FFODihydrofolate reductase 1.5.1.3 0.747
1e26 GPBDihydrofolate reductase 1.5.1.3 0.746
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.745
1hfq MOTDihydrofolate reductase 1.5.1.3 0.740
2d0k FOLDihydrofolate reductase 1.5.1.3 0.738
1dhf FOLDihydrofolate reductase 1.5.1.3 0.734
2w3m FOLDihydrofolate reductase 1.5.1.3 0.734
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.731
1u70 MTXDihydrofolate reductase 1.5.1.3 0.731
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.726
1dyj DDFDihydrofolate reductase 1.5.1.3 0.724
4keb FOLDihydrofolate reductase 1.5.1.3 0.721
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.718
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.718
4qi9 MTXDihydrofolate reductase / 0.717
1df7 MTXDihydrofolate reductase 1.5.1.3 0.714
3dfr MTXDihydrofolate reductase 1.5.1.3 0.713
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.710
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.707
1ohk COPDihydrofolate reductase 1.5.1.3 0.706
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.704
4m6l 21VDihydrofolate reductase 1.5.1.3 0.700
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.696
2dhf DZFDihydrofolate reductase 1.5.1.3 0.695
1ddr MTXDihydrofolate reductase 1.5.1.3 0.694
1u72 MTXDihydrofolate reductase 1.5.1.3 0.693
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.692
5ccc DDFDihydrofolate reductase 1.5.1.3 0.692
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.689
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.686
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.686
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.681
4p68 MTXDihydrofolate reductase / 0.680
1dhi MTXDihydrofolate reductase 1.5.1.3 0.678
3eig MTXDihydrofolate reductase 1.5.1.3 0.676
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.675
1re7 FOLDihydrofolate reductase 1.5.1.3 0.674
3ghv GHCDihydrofolate reductase 1.5.1.3 0.671
3ghw GHWDihydrofolate reductase 1.5.1.3 0.671
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.669
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.663
2vmy FFOSerine hydroxymethyltransferase / 0.662
3icr COACoenzyme A disulfide reductase / 0.655
1dds MTXDihydrofolate reductase 1.5.1.3 0.653
4fl0 PLPAminotransferase ALD1, chloroplastic 2.6.1 0.652
4x5j FOLDihydrofolate reductase 1.5.1.3 0.652
3zzf NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.651
8atc PALAspartate carbamoyltransferase catalytic subunit 2.1.3.2 0.651
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.650