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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zrx FMN Isopentenyl-diphosphate delta-isomerase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 1.271
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 1.243
2zry FNRIsopentenyl-diphosphate delta-isomerase / 1.216
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 1.210
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 1.203
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 1.194
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 1.183
2zru FMNIsopentenyl-diphosphate delta-isomerase / 1.173
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 1.076
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.756
1vhn FMNtRNA-dihydrouridine synthase / 0.755
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.749
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.746
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.743
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.743
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.737
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.732
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.728
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.728
2h8x FMNXenA / 0.726
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.724
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.723
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.719
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.718
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.718
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.715
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.714
4tmb FMNOld yellow enzyme / 0.712
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.711
3n19 FNRXenobiotic reductase / 0.702
1h63 FMNPentaerythritol tetranitrate reductase / 0.701
3oix FMNDihydroorotate dehydrogenase / 0.701
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.700
1z41 FMNNADPH dehydrogenase / 0.699
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.698
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.695
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.695
1gwj FMNMorphinone reductase / 0.694
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.694
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.693
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.693
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.692
1z48 FMNNADPH dehydrogenase / 0.688
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.686
4e2b FMNDehydrogenase / 0.684
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.682
3l5l FMNXenobiotic reductase / 0.682
4lwp SAHArginine N-methyltransferase, putative / 0.682
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.681
4jic FMNGTN Reductase / 0.681
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.679
3atz FMNProstaglandin F2a synthase / 0.679
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.678
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.678
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.678
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.676
1z44 FMNNADPH dehydrogenase / 0.676
2z6c FMNPhototropin-1 2.7.11.1 0.676
3p8i FMNPentaerythritol tetranitrate reductase / 0.676
3aty FMNProstaglandin F2a synthase / 0.675
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.674
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.674
4kuk RBFPutative blue-light photoreceptor / 0.672
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.672
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.670
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.669
3p8j FMNPentaerythritol tetranitrate reductase / 0.668
4utm FNRXenobiotic reductase / 0.668
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.667
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.666
3l67 FMNXenobiotic reductase / 0.666
2bf4 FMNNADPH--cytochrome P450 reductase / 0.665
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.665
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.662
4bmo FMNProtein NrdI / 0.662
3rpe FADPutative modulator of drug activity / 0.660
4m42 ATPDNA-directed DNA polymerase / 0.658
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.658
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.657
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.655
4e2d FMNDehydrogenase / 0.654
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.653
4fj5 DTPDNA-directed DNA polymerase / 0.653
4uth FMNXenobiotic reductase / 0.653
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.652
4ttc FMNIodotyrosine deiodinase 1 / 0.651
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.650
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.650
3ojw FMNNADPH--cytochrome P450 reductase / 0.650