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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zm1 KSF Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zm1 KSFTyrosine-protein kinase Lck 2.7.10.2 0.986
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.866
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.767
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.742
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.727
3lfa 1N1Mitogen-activated protein kinase 14 / 0.705
3ocg OCGMitogen-activated protein kinase 14 / 0.683
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.681
3l8x N4DMitogen-activated protein kinase 14 / 0.670
3u8w 09JMitogen-activated protein kinase 14 / 0.670
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.664
3bx5 304Mitogen-activated protein kinase 14 / 0.662
3fsf FSSMitogen-activated protein kinase 14 / 0.659
2gtm LIDMitogen-activated protein kinase 14 / 0.656
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.656
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.655
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.653
4gk4 L90Ephrin type-A receptor 3 2.7.10.1 0.651