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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yn8 STU Ephrin type-B receptor 4 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yn8 STUEphrin type-B receptor 4 2.7.10.1 1.037
3zew STUEphrin type-B receptor 4 2.7.10.1 0.915
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.867
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.863
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.846
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.814
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.805
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.805
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.797
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.787
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.784
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.780
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.778
1byg STUTyrosine-protein kinase CSK / 0.777
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.771
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.766
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.759
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.743
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.738
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.729
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.726
3d7t STUTyrosine-protein kinase CSK / 0.725
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.717
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.709
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.703
1x8b 824Wee1-like protein kinase 2.7.10.2 0.700
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.695
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.695
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.687
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.684
2io6 330Wee1-like protein kinase 2.7.10.2 0.683
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.679
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.670
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.667
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.662
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3biz 61EWee1-like protein kinase 2.7.10.2 0.657
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.653