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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yac 937 Serine/threonine-protein kinase PLK1 2.7.11.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 1.212
4a4l 939Serine/threonine-protein kinase PLK1 2.7.11.21 1.020
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.972
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.705
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.703
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.695
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.680
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.679
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.673
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.667
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.665
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.662
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.659
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.655
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.654
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.653
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.650
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.650
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.650