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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xmy CDK Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 1.046
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.768
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.764
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.763
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.741
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.740
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.730
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.728
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.713
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.710
2w17 I19Cyclin-dependent kinase 2 2.7.11.22 0.705
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.695
3qtz X42Cyclin-dependent kinase 2 2.7.11.22 0.693
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.688
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.686
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.683
4bbf O19Tyrosine-protein kinase JAK2 / 0.683
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.680
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.679
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.678
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.677
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.677
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.671
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.670
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.668
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.666
4dea NHIAurora kinase A 2.7.11.1 0.665
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.664
4acm 7YGCyclin-dependent kinase 2 2.7.11.22 0.664
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.663
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.663
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.661
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.660
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.660
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.659
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.659
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.659
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.659
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.659
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.655
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.654
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.654
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.653
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.652
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.652
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.650