Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xfk AA9 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xfk AA9Beta-secretase 1 3.4.23.46 1.429
2xfi XFIBeta-secretase 1 3.4.23.46 1.359
2viz VG4Beta-secretase 1 3.4.23.46 1.270
2xfj VG5Beta-secretase 1 3.4.23.46 1.231
2vj6 VG5Beta-secretase 1 3.4.23.46 1.228
2viy VG3Beta-secretase 1 3.4.23.46 1.201
2vnm CM8Beta-secretase 1 3.4.23.46 1.133
2vj7 VG6Beta-secretase 1 3.4.23.46 1.115
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.084
2vij C44Beta-secretase 1 3.4.23.46 1.065
2vj9 VG7Beta-secretase 1 3.4.23.46 1.052
2vie VG0Beta-secretase 1 3.4.23.46 1.045
2vnn CM7Beta-secretase 1 3.4.23.46 1.044
2wez ZYEBeta-secretase 1 3.4.23.46 1.038
4fco 0U4Beta-secretase 1 3.4.23.46 1.037
2b8l 5HABeta-secretase 1 3.4.23.46 1.026
2wf1 ZY1Beta-secretase 1 3.4.23.46 1.023
2wf3 ZY3Beta-secretase 1 3.4.23.46 1.017
2wf0 ZY0Beta-secretase 1 3.4.23.46 1.013
2wf4 ZY4Beta-secretase 1 3.4.23.46 1.010
2p8h MY9Beta-secretase 1 3.4.23.46 0.999
2b8v 3BNBeta-secretase 1 3.4.23.46 0.998
3veu 0GOBeta-secretase 1 3.4.23.46 0.929
2qzl IXSBeta-secretase 1 3.4.23.46 0.923
3ixj 586Beta-secretase 1 3.4.23.46 0.918
4exg 916Beta-secretase 1 3.4.23.46 0.909
3k5c 0BIBeta-secretase 1 3.4.23.46 0.906
2iqg F2IBeta-secretase 1 3.4.23.46 0.904
4ewo 996Beta-secretase 1 3.4.23.46 0.902
4gid 0GHBeta-secretase 1 3.4.23.46 0.901
4k9h 1QUBeta-secretase 1 3.4.23.46 0.896
4dpi 0N1Beta-secretase 1 3.4.23.46 0.883
2vkm BSDBeta-secretase 1 3.4.23.46 0.880
3lpj Z75Beta-secretase 1 3.4.23.46 0.880
3ohf 3HFBeta-secretase 1 3.4.23.46 0.879
4dpf 0LGBeta-secretase 1 3.4.23.46 0.876
3dm6 757Beta-secretase 1 3.4.23.46 0.875
3k5g BJCBeta-secretase 1 3.4.23.46 0.875
4ke1 1R6Beta-secretase 1 3.4.23.46 0.873
4ke0 1R8Beta-secretase 1 3.4.23.46 0.869
2p83 MR0Beta-secretase 1 3.4.23.46 0.867
3nsh 957Beta-secretase 1 3.4.23.46 0.864
4i0i 957Beta-secretase 1 3.4.23.46 0.864
4k8s 1QTBeta-secretase 1 3.4.23.46 0.852
3cib 314Beta-secretase 1 3.4.23.46 0.841
3r2f PB0Beta-secretase 1 3.4.23.46 0.840
3ohh 3HHBeta-secretase 1 3.4.23.46 0.838
3qi1 C6ABeta-secretase 1 3.4.23.46 0.832
3cic 316Beta-secretase 1 3.4.23.46 0.831
2oah QINBeta-secretase 1 3.4.23.46 0.812
3pi5 3P5Beta-secretase 1 3.4.23.46 0.809
4dus 0MPBeta-secretase 1 3.4.23.46 0.807
3cid 318Beta-secretase 1 3.4.23.46 0.805
4i0h 1BLBeta-secretase 1 3.4.23.46 0.799
3pww ROCEndothiapepsin 3.4.23.22 0.796
1w51 L01Beta-secretase 1 3.4.23.46 0.793
2hiz LIJBeta-secretase 1 3.4.23.46 0.791
2fdp FRPBeta-secretase 1 3.4.23.46 0.784
4lxk 1YTBeta-secretase 1 3.4.23.46 0.777
3tpr 5HABeta-secretase 1 3.4.23.46 0.775
3lpk Z76Beta-secretase 1 3.4.23.46 0.771
4lxa 1YSBeta-secretase 1 3.4.23.46 0.761
3dv1 AR9Beta-secretase 1 3.4.23.46 0.756
2f3f AXFBeta-secretase 1 3.4.23.46 0.753
2p4j 23IBeta-secretase 1 3.4.23.46 0.753
3qbh QBHBeta-secretase 1 3.4.23.46 0.752
3vf3 0GSBeta-secretase 1 3.4.23.46 0.740
3dv5 BAVBeta-secretase 1 3.4.23.46 0.732
3duy AFJBeta-secretase 1 3.4.23.46 0.729
3lpi Z74Beta-secretase 1 3.4.23.46 0.726
2hm1 LIQBeta-secretase 1 3.4.23.46 0.702
2jjj 0QSEndothiapepsin 3.4.23.22 0.699
1e80 0GQEndothiapepsin 3.4.23.22 0.689
3vg1 0GTBeta-secretase 1 3.4.23.46 0.686
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.685
1eag A70Candidapepsin-2 3.4.23.24 0.683
2g94 ZPQBeta-secretase 1 3.4.23.46 0.683
3k5d XLIBeta-secretase 1 3.4.23.46 0.683
4d89 BXDBeta-secretase 1 3.4.23.46 0.683
3own 3OXRenin 3.4.23.15 0.675
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.674
1qrp HH0Pepsin A-4 3.4.23.1 0.672
2f3e AXQBeta-secretase 1 3.4.23.46 0.672
1psa 0ZLPepsin A 3.4.23.1 0.666
3k5f AYHBeta-secretase 1 3.4.23.46 0.661
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.660
3i25 MV7Beta-secretase 1 3.4.23.46 0.655