Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xfi XFI Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xfi XFIBeta-secretase 1 3.4.23.46 1.379
2xfk AA9Beta-secretase 1 3.4.23.46 1.359
2viy VG3Beta-secretase 1 3.4.23.46 1.182
2viz VG4Beta-secretase 1 3.4.23.46 1.174
2vj6 VG5Beta-secretase 1 3.4.23.46 1.173
2xfj VG5Beta-secretase 1 3.4.23.46 1.173
2vnm CM8Beta-secretase 1 3.4.23.46 1.066
2vj7 VG6Beta-secretase 1 3.4.23.46 1.056
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.037
4fco 0U4Beta-secretase 1 3.4.23.46 1.025
2vij C44Beta-secretase 1 3.4.23.46 1.017
2wez ZYEBeta-secretase 1 3.4.23.46 1.014
2vnn CM7Beta-secretase 1 3.4.23.46 1.012
2b8v 3BNBeta-secretase 1 3.4.23.46 1.010
2b8l 5HABeta-secretase 1 3.4.23.46 1.008
2wf3 ZY3Beta-secretase 1 3.4.23.46 1.000
2vie VG0Beta-secretase 1 3.4.23.46 0.993
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.992
2vj9 VG7Beta-secretase 1 3.4.23.46 0.985
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.981
2p8h MY9Beta-secretase 1 3.4.23.46 0.975
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.962
3veu 0GOBeta-secretase 1 3.4.23.46 0.923
4ewo 996Beta-secretase 1 3.4.23.46 0.923
4exg 916Beta-secretase 1 3.4.23.46 0.911
4dpf 0LGBeta-secretase 1 3.4.23.46 0.910
4gid 0GHBeta-secretase 1 3.4.23.46 0.899
2p83 MR0Beta-secretase 1 3.4.23.46 0.896
3nsh 957Beta-secretase 1 3.4.23.46 0.895
4i0i 957Beta-secretase 1 3.4.23.46 0.895
2iqg F2IBeta-secretase 1 3.4.23.46 0.891
3dm6 757Beta-secretase 1 3.4.23.46 0.891
3k5c 0BIBeta-secretase 1 3.4.23.46 0.889
2vkm BSDBeta-secretase 1 3.4.23.46 0.886
3ohf 3HFBeta-secretase 1 3.4.23.46 0.879
4dpi 0N1Beta-secretase 1 3.4.23.46 0.874
3k5g BJCBeta-secretase 1 3.4.23.46 0.872
4k9h 1QUBeta-secretase 1 3.4.23.46 0.872
4k8s 1QTBeta-secretase 1 3.4.23.46 0.870
3lpj Z75Beta-secretase 1 3.4.23.46 0.868
4dus 0MPBeta-secretase 1 3.4.23.46 0.866
4ke1 1R6Beta-secretase 1 3.4.23.46 0.855
4ke0 1R8Beta-secretase 1 3.4.23.46 0.850
3cic 316Beta-secretase 1 3.4.23.46 0.848
3qi1 C6ABeta-secretase 1 3.4.23.46 0.848
3ohh 3HHBeta-secretase 1 3.4.23.46 0.839
3cid 318Beta-secretase 1 3.4.23.46 0.822
3lpk Z76Beta-secretase 1 3.4.23.46 0.819
3cib 314Beta-secretase 1 3.4.23.46 0.818
2qzl IXSBeta-secretase 1 3.4.23.46 0.815
3pi5 3P5Beta-secretase 1 3.4.23.46 0.811
3r2f PB0Beta-secretase 1 3.4.23.46 0.804
3tpr 5HABeta-secretase 1 3.4.23.46 0.793
3vf3 0GSBeta-secretase 1 3.4.23.46 0.788
2fdp FRPBeta-secretase 1 3.4.23.46 0.786
4i0h 1BLBeta-secretase 1 3.4.23.46 0.785
4lxk 1YTBeta-secretase 1 3.4.23.46 0.785
1w51 L01Beta-secretase 1 3.4.23.46 0.783
2oah QINBeta-secretase 1 3.4.23.46 0.782
3pww ROCEndothiapepsin 3.4.23.22 0.782
4lxa 1YSBeta-secretase 1 3.4.23.46 0.778
2hm1 LIQBeta-secretase 1 3.4.23.46 0.772
3lpi Z74Beta-secretase 1 3.4.23.46 0.767
3n4l 842Beta-secretase 1 3.4.23.46 0.763
3qbh QBHBeta-secretase 1 3.4.23.46 0.759
3dv5 BAVBeta-secretase 1 3.4.23.46 0.735
4i0j 842Beta-secretase 1 3.4.23.46 0.732
3dv1 AR9Beta-secretase 1 3.4.23.46 0.731
2hiz LIJBeta-secretase 1 3.4.23.46 0.729
3duy AFJBeta-secretase 1 3.4.23.46 0.703
4d89 BXDBeta-secretase 1 3.4.23.46 0.695
2f3e AXQBeta-secretase 1 3.4.23.46 0.693
1e80 0GQEndothiapepsin 3.4.23.22 0.690
1xe6 5FPPlasmepsin-2 3.4.23.39 0.686
2jjj 0QSEndothiapepsin 3.4.23.22 0.686
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.685
2g94 ZPQBeta-secretase 1 3.4.23.46 0.678
3k5f AYHBeta-secretase 1 3.4.23.46 0.677
3own 3OXRenin 3.4.23.15 0.677
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.673
3vg1 0GTBeta-secretase 1 3.4.23.46 0.672
3k5d XLIBeta-secretase 1 3.4.23.46 0.670
3i25 MV7Beta-secretase 1 3.4.23.46 0.665
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.659
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.655