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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xb7 GUI ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 1.089
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.795
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.769
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.712
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.698
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.694
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.690
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.685
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.683
4j52 1J3Serine/threonine-protein kinase PLK1 2.7.11.21 0.677
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.669
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.669
1oec AA2Fibroblast growth factor receptor 2 / 0.667
2p2h 994Vascular endothelial growth factor receptor 2 2.7.10.1 0.667
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.661
4bbf O19Tyrosine-protein kinase JAK2 / 0.660
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.658
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.656
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.656
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.653
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.651
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.651
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.650