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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x2m X2M Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.878
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.836
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.740
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.725
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.723
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.719
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.689
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.689
2jav 5Z5Serine/threonine-protein kinase Nek2 2.7.11.1 0.688
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.688
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.686
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.681
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.680
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.680
2bfy H1NAurora kinase B-A 2.7.11.1 0.678
4aw5 30KEphrin type-B receptor 4 2.7.10.1 0.675
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.667
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.667
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.662
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
2wti WTISerine/threonine-protein kinase Chk2 2.7.11.1 0.657
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4mcv 29KProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.653
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.652
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.652