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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x2l X2L Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.943
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.780
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.740
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.693
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.687
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.680
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.675
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.666
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.660
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.657
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.650