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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wip P49 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wip P49Cyclin-dependent kinase 2 2.7.11.22 1.064
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.793
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.749
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.744
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.734
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.730
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.727
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.726
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.721
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.717
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.704
2bkz SBCCyclin-dependent kinase 2 2.7.11.22 0.703
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.692
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.691
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.689
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.689
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.684
3ttj JBIMitogen-activated protein kinase 10 2.7.11.24 0.682
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.678
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.672
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.671
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.671
4dea NHIAurora kinase A 2.7.11.1 0.671
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.670
4b99 R4LMitogen-activated protein kinase 7 2.7.11.24 0.669
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.668
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.664
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.664
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.662
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.661
2etm 7PYFocal adhesion kinase 1 2.7.10.2 0.660
3cgo JNOMitogen-activated protein kinase 10 2.7.11.24 0.660
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.659
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.656
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.656
1oec AA2Fibroblast growth factor receptor 2 / 0.655
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.655
1q3w ATUGlycogen synthase kinase-3 beta 2.7.11.26 0.654
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.651