Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wf2 ZY2 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.264
2vnm CM8Beta-secretase 1 3.4.23.46 1.126
2wf3 ZY3Beta-secretase 1 3.4.23.46 1.120
2wf1 ZY1Beta-secretase 1 3.4.23.46 1.116
2wez ZYEBeta-secretase 1 3.4.23.46 1.109
2vj7 VG6Beta-secretase 1 3.4.23.46 1.093
2vij C44Beta-secretase 1 3.4.23.46 1.091
2xfj VG5Beta-secretase 1 3.4.23.46 1.088
2vnn CM7Beta-secretase 1 3.4.23.46 1.087
2wf0 ZY0Beta-secretase 1 3.4.23.46 1.085
2viz VG4Beta-secretase 1 3.4.23.46 1.084
2xfk AA9Beta-secretase 1 3.4.23.46 1.084
2vj6 VG5Beta-secretase 1 3.4.23.46 1.055
4fco 0U4Beta-secretase 1 3.4.23.46 1.045
2xfi XFIBeta-secretase 1 3.4.23.46 1.037
2b8l 5HABeta-secretase 1 3.4.23.46 1.027
2wf4 ZY4Beta-secretase 1 3.4.23.46 1.024
2vj9 VG7Beta-secretase 1 3.4.23.46 1.015
2vie VG0Beta-secretase 1 3.4.23.46 1.009
2viy VG3Beta-secretase 1 3.4.23.46 0.985
2b8v 3BNBeta-secretase 1 3.4.23.46 0.974
2p8h MY9Beta-secretase 1 3.4.23.46 0.966
4dpf 0LGBeta-secretase 1 3.4.23.46 0.961
3veu 0GOBeta-secretase 1 3.4.23.46 0.941
4dpi 0N1Beta-secretase 1 3.4.23.46 0.927
3k5g BJCBeta-secretase 1 3.4.23.46 0.901
2vkm BSDBeta-secretase 1 3.4.23.46 0.893
3ohf 3HFBeta-secretase 1 3.4.23.46 0.891
4exg 916Beta-secretase 1 3.4.23.46 0.887
3dm6 757Beta-secretase 1 3.4.23.46 0.886
3nsh 957Beta-secretase 1 3.4.23.46 0.880
4i0i 957Beta-secretase 1 3.4.23.46 0.880
2qzl IXSBeta-secretase 1 3.4.23.46 0.877
4k9h 1QUBeta-secretase 1 3.4.23.46 0.871
3dv5 BAVBeta-secretase 1 3.4.23.46 0.865
1w51 L01Beta-secretase 1 3.4.23.46 0.862
3k5c 0BIBeta-secretase 1 3.4.23.46 0.862
3cib 314Beta-secretase 1 3.4.23.46 0.858
3cic 316Beta-secretase 1 3.4.23.46 0.846
3ixj 586Beta-secretase 1 3.4.23.46 0.842
4gid 0GHBeta-secretase 1 3.4.23.46 0.839
4k8s 1QTBeta-secretase 1 3.4.23.46 0.837
3ohh 3HHBeta-secretase 1 3.4.23.46 0.831
3r2f PB0Beta-secretase 1 3.4.23.46 0.826
3qi1 C6ABeta-secretase 1 3.4.23.46 0.822
3qbh QBHBeta-secretase 1 3.4.23.46 0.814
2fdp FRPBeta-secretase 1 3.4.23.46 0.813
4ewo 996Beta-secretase 1 3.4.23.46 0.808
4ke1 1R6Beta-secretase 1 3.4.23.46 0.807
3i25 MV7Beta-secretase 1 3.4.23.46 0.795
4lxk 1YTBeta-secretase 1 3.4.23.46 0.791
3pi5 3P5Beta-secretase 1 3.4.23.46 0.789
4ke0 1R8Beta-secretase 1 3.4.23.46 0.783
3k5f AYHBeta-secretase 1 3.4.23.46 0.778
3pww ROCEndothiapepsin 3.4.23.22 0.777
2oah QINBeta-secretase 1 3.4.23.46 0.773
3lpj Z75Beta-secretase 1 3.4.23.46 0.760
3ixk 929Beta-secretase 1 3.4.23.46 0.759
2hiz LIJBeta-secretase 1 3.4.23.46 0.752
2p83 MR0Beta-secretase 1 3.4.23.46 0.750
3lpk Z76Beta-secretase 1 3.4.23.46 0.735
3cid 318Beta-secretase 1 3.4.23.46 0.727
3vf3 0GSBeta-secretase 1 3.4.23.46 0.721
1od1 0QSEndothiapepsin 3.4.23.22 0.712
2ntr L00Beta-secretase 1 3.4.23.46 0.708
2p4j 23IBeta-secretase 1 3.4.23.46 0.706
1w6h TITPlasmepsin-2 3.4.23.39 0.705
2g94 ZPQBeta-secretase 1 3.4.23.46 0.704
3n4l 842Beta-secretase 1 3.4.23.46 0.704
2hm1 LIQBeta-secretase 1 3.4.23.46 0.702
1e80 0GQEndothiapepsin 3.4.23.22 0.700
3lpi Z74Beta-secretase 1 3.4.23.46 0.698
3dv1 AR9Beta-secretase 1 3.4.23.46 0.694
2f3e AXQBeta-secretase 1 3.4.23.46 0.692
1gvv 0GMEndothiapepsin 3.4.23.22 0.689
3own 3OXRenin 3.4.23.15 0.688
2ph6 712Beta-secretase 1 3.4.23.46 0.684
4y38 0A9Endothiapepsin 3.4.23.22 0.683
1e82 M90Endothiapepsin 3.4.23.22 0.682
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.675
3vg1 0GTBeta-secretase 1 3.4.23.46 0.675
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.674
1gvt 2ZSEndothiapepsin 3.4.23.22 0.674
3k5d XLIBeta-secretase 1 3.4.23.46 0.673
3duy AFJBeta-secretase 1 3.4.23.46 0.670
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.662
3nxe 2NCProtease / 0.653
1gvw 0EMEndothiapepsin 3.4.23.22 0.652
1eag A70Candidapepsin-2 3.4.23.24 0.651
1e81 M91Endothiapepsin 3.4.23.22 0.650
1rne C60Renin 3.4.23.15 0.650