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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w5b AGS Serine/threonine-protein kinase Nek2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.921
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.715
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.707
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.700
4lv5 ADPRhoptry protein 5B / 0.698
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.697
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.695
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.694
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.681
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.679
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.679
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.676
1zyd ATPeIF-2-alpha kinase GCN2 / 0.675
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.672
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.671
3b2t M33Fibroblast growth factor receptor 2 / 0.665
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.664
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.663
1ir3 ANPInsulin receptor 2.7.10.1 0.659
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.659
2pvy ACPFibroblast growth factor receptor 2 / 0.659
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.659
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.656
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.656
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.655
3w0n ANPHygromycin-B 4-O-kinase 2.7.1.163 0.655
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.654
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.654
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.654
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.654
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.654
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.653
4xhg ADPUncharacterized protein / 0.653
4mv3 ACPBiotin carboxylase 6.3.4.14 0.652
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.652
1h7u AGSMismatch repair endonuclease PMS2 3.1 0.650