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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w3w VG9 Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w3w VG9Dihydrofolate reductase / 1.063
4e5i 0N9Polymerase acidic protein / 0.744
1kms LIHDihydrofolate reductase 1.5.1.3 0.707
1kmv LIIDihydrofolate reductase 1.5.1.3 0.702
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.666
4e5f 0N7Polymerase acidic protein / 0.660
4m2x TMQDihydrofolate reductase 1.5.1.3 0.657
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.653
1dre MTXDihydrofolate reductase 1.5.1.3 0.651
4ixf IXFDihydrofolate reductase 1.5.1.3 0.651