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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w3b NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w3b NDPDihydrofolate reductase 1.5.1.3 1.290
3nxx NDPDihydrofolate reductase 1.5.1.3 1.175
8dfr NDPDihydrofolate reductase 1.5.1.3 1.173
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.109
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.065
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.061
3d84 NDPDihydrofolate reductase 1.5.1.3 0.931
4m6j NDPDihydrofolate reductase 1.5.1.3 0.921
3tqa NDPDihydrofolate reductase / 0.867
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.859
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.841
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.837
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.825
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.804
2cig 1DGDihydrofolate reductase 1.5.1.3 0.789
1juv NDPDihydrofolate reductase 1.5.1.3 0.774
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.774
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.759
5ecc NAPDehydrofolate reductase type I / 0.753
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.731
1m78 NDPDihydrofolate reductase 1.5.1.3 0.726
1drh NAPDihydrofolate reductase 1.5.1.3 0.723
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.719
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.719
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.717
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.711
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.710
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.710
5a04 NDPGlucose-fructose oxidoreductase / 0.700
2xw7 NDPDihydrofolate reductase / 0.695
3qlr NDPDihydrofolate reductase 1.5.1.3 0.682
5a03 NDPGlucose-fructose oxidoreductase / 0.674
5a05 NDPGlucose-fructose oxidoreductase / 0.667
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.664
3qls NDPDihydrofolate reductase 1.5.1.3 0.655
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.653
4ha9 NDP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 0.650