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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w0d CGS Macrophage metalloelastase 3.4.24.65

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w0d CGSMacrophage metalloelastase 3.4.24.65 0.965
3oho Z79Stromelysin-1 3.4.24.17 0.826
4g9l NGHStromelysin-1 3.4.24.17 0.809
4ja1 NGHStromelysin-1 3.4.24.17 0.801
4h76 10BMacrophage metalloelastase 3.4.24.65 0.775
4h49 L29Macrophage metalloelastase 3.4.24.65 0.760
1bqo N25Stromelysin-1 3.4.24.17 0.750
4dpe NGHStromelysin-1 3.4.24.17 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1d8f SPIStromelysin-1 3.4.24.17 0.739
1d8m BBHStromelysin-1 3.4.24.17 0.725
2ow1 7MRMatrix metalloproteinase-9 3.4.24.35 0.718
1g05 BBHStromelysin-1 3.4.24.17 0.714
1zxc IH6Disintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 0.704
2i47 KGYDisintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 0.694
3zxh E41Collagenase 3 3.4.24 0.694
3kry 3KRCollagenase 3 3.4.24 0.693
1d7x SPCStromelysin-1 3.4.24.17 0.682
1jk3 BATMacrophage metalloelastase 3.4.24.65 0.678
1q3a NGHStromelysin-2 3.4.24.22 0.673
4i03 L88Macrophage metalloelastase 3.4.24.65 0.673
1b3d S27Stromelysin-1 3.4.24.17 0.670
4h30 0ZDMacrophage metalloelastase 3.4.24.65 0.668
1yqy 915Lethal factor 3.4.24.83 0.667
1atl 0QISnake venom metalloproteinase atrolysin-D 3.4.24.42 0.663
1fm1 WAYCollagenase 3 3.4.24 0.659
1ciz DPSStromelysin-1 3.4.24.17 0.656
1bzs BSINeutrophil collagenase 3.4.24.34 0.654
3kds NHXATP-dependent zinc metalloprotease FtsH / 0.651