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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vu3 LZE Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2vu3 LZECyclin-dependent kinase 2 2.7.11.22 0.937
2vtq LZACyclin-dependent kinase 2 2.7.11.22 0.850
2vtt LZDCyclin-dependent kinase 2 2.7.11.22 0.768
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2vto LZ8Cyclin-dependent kinase 2 2.7.11.22 0.689
2vtp LZ9Cyclin-dependent kinase 2 2.7.11.22 0.673
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
3wbl PDYCyclin-dependent kinase 2 2.7.11.22 0.659
2vtn LZ7Cyclin-dependent kinase 2 2.7.11.22 0.657
3vf8 0JETyrosine-protein kinase SYK 2.7.10.2 0.653