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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vrx 447 Aurora kinase B-A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vrx 447Aurora kinase B-A 2.7.11.1 1.105
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4btk DTQTau-tubulin kinase 1 2.7.11.1 0.714
2vgp AD6Aurora kinase B-A 2.7.11.1 0.671
4bdc ODHSerine/threonine-protein kinase Chk2 2.7.11.1 0.669
2ym8 YM8Serine/threonine-protein kinase Chk1 2.7.11.1 0.667
3ztx ZTXAurora kinase B-A 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.652