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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vie VG0 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vie VG0Beta-secretase 1 3.4.23.46 1.314
2vj7 VG6Beta-secretase 1 3.4.23.46 1.174
2vj6 VG5Beta-secretase 1 3.4.23.46 1.137
2xfj VG5Beta-secretase 1 3.4.23.46 1.135
2viz VG4Beta-secretase 1 3.4.23.46 1.129
2vj9 VG7Beta-secretase 1 3.4.23.46 1.125
2vnm CM8Beta-secretase 1 3.4.23.46 1.120
2wf0 ZY0Beta-secretase 1 3.4.23.46 1.115
2vnn CM7Beta-secretase 1 3.4.23.46 1.074
2wez ZYEBeta-secretase 1 3.4.23.46 1.063
2xfk AA9Beta-secretase 1 3.4.23.46 1.045
2wf1 ZY1Beta-secretase 1 3.4.23.46 1.035
2viy VG3Beta-secretase 1 3.4.23.46 1.023
2vij C44Beta-secretase 1 3.4.23.46 1.016
2wf4 ZY4Beta-secretase 1 3.4.23.46 1.015
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.009
2b8v 3BNBeta-secretase 1 3.4.23.46 1.008
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.999
2xfi XFIBeta-secretase 1 3.4.23.46 0.993
4dus 0MPBeta-secretase 1 3.4.23.46 0.957
3k5c 0BIBeta-secretase 1 3.4.23.46 0.951
3nsh 957Beta-secretase 1 3.4.23.46 0.929
4i0i 957Beta-secretase 1 3.4.23.46 0.929
2iqg F2IBeta-secretase 1 3.4.23.46 0.922
4exg 916Beta-secretase 1 3.4.23.46 0.918
4dpf 0LGBeta-secretase 1 3.4.23.46 0.905
4ewo 996Beta-secretase 1 3.4.23.46 0.905
3lpk Z76Beta-secretase 1 3.4.23.46 0.880
3cib 314Beta-secretase 1 3.4.23.46 0.877
4i0h 1BLBeta-secretase 1 3.4.23.46 0.877
4dpi 0N1Beta-secretase 1 3.4.23.46 0.876
4ke0 1R8Beta-secretase 1 3.4.23.46 0.869
2p83 MR0Beta-secretase 1 3.4.23.46 0.865
3lpj Z75Beta-secretase 1 3.4.23.46 0.850
3ohf 3HFBeta-secretase 1 3.4.23.46 0.850
2qzl IXSBeta-secretase 1 3.4.23.46 0.841
3ohh 3HHBeta-secretase 1 3.4.23.46 0.831
2hiz LIJBeta-secretase 1 3.4.23.46 0.830
3pww ROCEndothiapepsin 3.4.23.22 0.829
3qi1 C6ABeta-secretase 1 3.4.23.46 0.826
3tpr 5HABeta-secretase 1 3.4.23.46 0.826
4ke1 1R6Beta-secretase 1 3.4.23.46 0.826
1w51 L01Beta-secretase 1 3.4.23.46 0.821
3i25 MV7Beta-secretase 1 3.4.23.46 0.820
2oah QINBeta-secretase 1 3.4.23.46 0.816
4k8s 1QTBeta-secretase 1 3.4.23.46 0.815
3ixj 586Beta-secretase 1 3.4.23.46 0.814
3cic 316Beta-secretase 1 3.4.23.46 0.812
4lxm 1YUBeta-secretase 1 3.4.23.46 0.811
3dm6 757Beta-secretase 1 3.4.23.46 0.810
2fdp FRPBeta-secretase 1 3.4.23.46 0.807
2hm1 LIQBeta-secretase 1 3.4.23.46 0.804
4lxa 1YSBeta-secretase 1 3.4.23.46 0.803
2vkm BSDBeta-secretase 1 3.4.23.46 0.802
3k5f AYHBeta-secretase 1 3.4.23.46 0.792
4k9h 1QUBeta-secretase 1 3.4.23.46 0.787
3pi5 3P5Beta-secretase 1 3.4.23.46 0.781
4dh6 0KNBeta-secretase 1 3.4.23.46 0.781
4i0j 842Beta-secretase 1 3.4.23.46 0.777
3cid 318Beta-secretase 1 3.4.23.46 0.773
3vf3 0GSBeta-secretase 1 3.4.23.46 0.772
2p8h MY9Beta-secretase 1 3.4.23.46 0.771
3lpi Z74Beta-secretase 1 3.4.23.46 0.767
2b8l 5HABeta-secretase 1 3.4.23.46 0.766
4fco 0U4Beta-secretase 1 3.4.23.46 0.757
3qbh QBHBeta-secretase 1 3.4.23.46 0.749
4d89 BXDBeta-secretase 1 3.4.23.46 0.737
2f3e AXQBeta-secretase 1 3.4.23.46 0.727
3vg1 0GTBeta-secretase 1 3.4.23.46 0.726
2g94 ZPQBeta-secretase 1 3.4.23.46 0.723
3dv1 AR9Beta-secretase 1 3.4.23.46 0.723
4gid 0GHBeta-secretase 1 3.4.23.46 0.722
1gvv 0GMEndothiapepsin 3.4.23.22 0.712
2ntr L00Beta-secretase 1 3.4.23.46 0.711
3n4l 842Beta-secretase 1 3.4.23.46 0.708
2jjj 0QSEndothiapepsin 3.4.23.22 0.702
3veu 0GOBeta-secretase 1 3.4.23.46 0.698
3k5d XLIBeta-secretase 1 3.4.23.46 0.694
1bil 0IURenin 3.4.23.15 0.689
2f3f AXFBeta-secretase 1 3.4.23.46 0.688
3duy AFJBeta-secretase 1 3.4.23.46 0.682
3own 3OWRenin 3.4.23.15 0.662
1w6h TITPlasmepsin-2 3.4.23.39 0.660
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.655
3dv5 BAVBeta-secretase 1 3.4.23.46 0.651