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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vet UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vet UMPThymidylate synthase / 0.994
2fto TMPThymidylate synthase / 0.855
1bid UMPThymidylate synthase / 0.841
4isk UMPThymidylate synthase / 0.834
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.831
4e5o UMPThymidylate synthase 2.1.1.45 0.826
5by6 UMPThymidylate synthase / 0.823
4h0u UMPThymidylate synthase / 0.816
1njc DCMThymidylate synthase / 0.809
4irr UMPThymidylate synthase / 0.806
4ein NOHThymidylate synthase 2.1.1.45 0.800
3qj7 UMPThymidylate synthase ThyA / 0.790
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.785
1tdu DURThymidylate synthase / 0.782
3bgx TMPThymidylate synthase / 0.782
2g8a UMPThymidylate synthase / 0.776
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.775
1tsy UMPThymidylate synthase / 0.773
4dq1 UMPThymidylate synthase / 0.767
4eb4 UMPThymidylate synthase 2.1.1.45 0.762
1tys TMPThymidylate synthase / 0.757
1f28 UMPThymidylate synthase 2.1.1.45 0.755
1nja DCMThymidylate synthase / 0.754
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.754
1bp0 UMPThymidylate synthase / 0.750
2tdm UMPThymidylate synthase / 0.738
1ddu DDUThymidylate synthase / 0.736
2g86 UMPThymidylate synthase / 0.736
1jmg UMPThymidylate synthase / 0.728
1vzb UMPThymidylate synthase / 0.728
4psg NOHThymidylate synthase / 0.726
1tdc UMPThymidylate synthase / 0.724
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.721
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.719
1tsv UMPThymidylate synthase / 0.719
2tsr UMPThymidylate synthase 2.1.1.45 0.719
4iqq UMPThymidylate synthase / 0.716
1njd UMPThymidylate synthase / 0.715
1bpj UMPThymidylate synthase / 0.704
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.703
2g8d UMPThymidylate synthase / 0.703
1jmf UMPThymidylate synthase / 0.702
1vza UMPThymidylate synthase / 0.695
1bp6 UMPThymidylate synthase / 0.693
4fox UMPThymidylate synthase ThyA / 0.690
1jmi UMPThymidylate synthase / 0.687
1tsx UMPThymidylate synthase / 0.683
1bdu DURThymidylate synthase / 0.674
1njb UMPThymidylate synthase / 0.672
1jmh UMPThymidylate synthase / 0.667