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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2v3o I26 Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2v3o I26Prothrombin 3.4.21.5 1.051
2znk 31UProthrombin 3.4.21.5 0.802
4bao MVFProthrombin 3.4.21.5 0.785
4bak M67Prothrombin 3.4.21.5 0.782
2zg0 50UProthrombin 3.4.21.5 0.772
4bah MELProthrombin 3.4.21.5 0.771
2ziq 26UProthrombin 3.4.21.5 0.769
1ypm RA4Prothrombin 3.4.21.5 0.767
1ype UIPProthrombin 3.4.21.5 0.761
2cf9 348Prothrombin 3.4.21.5 0.758
1k22 MELProthrombin 3.4.21.5 0.756
4bam MM9Prothrombin 3.4.21.5 0.756
4ban M6SProthrombin 3.4.21.5 0.756
2zfr 46UProthrombin 3.4.21.5 0.750
2bdy UNBProthrombin 3.4.21.5 0.745
4ax9 N5NProthrombin 3.4.21.5 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1ypl RA8Prothrombin 3.4.21.5 0.743
2zda 32UProthrombin 3.4.21.5 0.743
2zhe 13UProthrombin 3.4.21.5 0.727
4ayv 9MQProthrombin 3.4.21.5 0.715
3v0x ANHCationic trypsin 3.4.21.4 0.713
1c5n ESIProthrombin 3.4.21.5 0.712
2gde SN3Prothrombin 3.4.21.5 0.706
3plp BBACationic trypsin 3.4.21.4 0.704
1c4v IH2Prothrombin 3.4.21.5 0.702
4az2 9MUProthrombin 3.4.21.5 0.698
3utu 1TSProthrombin 3.4.21.5 0.696
4baq M4ZProthrombin 3.4.21.5 0.695
1lpk CBBCoagulation factor X 3.4.21.6 0.692
2zhq 27UProthrombin 3.4.21.5 0.688
1ae8 AZLProthrombin 3.4.21.5 0.682
1gj4 132Prothrombin 3.4.21.5 0.682
3biv 11UProthrombin 3.4.21.5 0.682
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.681
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.681
1d4p BPPProthrombin 3.4.21.5 0.680
2zhf 49UProthrombin 3.4.21.5 0.679
2zi2 24UProthrombin 3.4.21.5 0.677
1c1u BAIProthrombin 3.4.21.5 0.675
2v3h I25Prothrombin 3.4.21.5 0.674
2a2x NA9Prothrombin 3.4.21.5 0.669
1vzq SHYProthrombin 3.4.21.5 0.666
4e7r 0NWProthrombin 3.4.21.5 0.665
1ypj UIBProthrombin 3.4.21.5 0.664
2cn0 F25Prothrombin 3.4.21.5 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1kts C24Prothrombin 3.4.21.5 0.658
2cf8 ESHProthrombin 3.4.21.5 0.653