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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r64 740 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.941
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.754
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.739
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.738
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.732
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.718
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.716
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.712
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.712
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.709
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.691
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.690
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.687
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.685
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.682
3rpo 24ZCyclin-dependent kinase 2 2.7.11.22 0.679
3ggf GVDSerine/threonine-protein kinase 26 / 0.675
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.674
4f63 0S7Fibroblast growth factor receptor 1 / 0.673
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.670
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.670
3r8l Z30Cyclin-dependent kinase 2 2.7.11.22 0.669
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.668
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.666
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.666
3rm7 19ZCyclin-dependent kinase 2 2.7.11.22 0.665
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.665
3ig7 EFPCyclin-dependent kinase 2 2.7.11.22 0.664
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.663
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.662
3rai X85Cyclin-dependent kinase 2 2.7.11.22 0.661
3w1f 1O5Dual specificity protein kinase TTK 2.7.12.1 0.661
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.660
3r7y Z04Cyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.658
4f64 0S8Fibroblast growth factor receptor 1 / 0.658
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.657
3r71 X86Cyclin-dependent kinase 2 2.7.11.22 0.656
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.656
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.655
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.653
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.652
2btr U73Cyclin-dependent kinase 2 2.7.11.22 0.651
3dcv 55ESerine/threonine-protein kinase pim-1 2.7.11.1 0.651
3vid 4TTVascular endothelial growth factor receptor 2 2.7.10.1 0.651