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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r2n KYN Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2r2n KYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.834
4ubs DIFPentalenic acid synthase 1.14.15.11 0.679
1toi HCIAspartate aminotransferase 2.6.1.1 0.671
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.665
4bqs K2QShikimate kinase 2.7.1.71 0.665
3ar4 ATPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.662
4kig ENOPhenylpyruvate C(3)-methyltransferase 2.1.1.281 0.661
4isu IKMGlutamate receptor 2 / 0.660
3mvw BHZNickel-binding periplasmic protein / 0.658
2ay3 MPPAromatic-amino-acid aminotransferase 2.6.1.57 0.656
2zfa FMNLactate oxidase / 0.655
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.654
3b1d PLSBetaC-S lyase / 0.653
1wuq 8GTGTP cyclohydrolase 1 / 0.652
3mw0 BHRNickel-binding periplasmic protein / 0.652
3q7d NPXProstaglandin G/H synthase 2 1.14.99.1 0.651