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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qxw LDT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qxw LDTAldose reductase 1.1.1.21 1.141
3ghr LDTAldose reductase 1.1.1.21 1.103
2i17 LDTAldose reductase 1.1.1.21 1.101
1us0 LDTAldose reductase 1.1.1.21 1.100
2i16 LDTAldose reductase 1.1.1.21 1.100
3ghs LDTAldose reductase 1.1.1.21 1.099
3lz5 LDTAldose reductase 1.1.1.21 1.081
3ld5 LDTAldose reductase 1.1.1.21 1.073
3lbo LDTAldose reductase 1.1.1.21 1.060
3lql LDTAldose reductase 1.1.1.21 1.055
3ght LDTAldose reductase 1.1.1.21 1.050
3ghu LDTAldose reductase 1.1.1.21 1.049
3m4h 388Aldose reductase 1.1.1.21 0.978
2iki 388Aldose reductase 1.1.1.21 0.976
2ikj 393Aldose reductase 1.1.1.21 0.870
3t42 3T4Aldose reductase 1.1.1.21 0.812
2pdj 393Aldose reductase 1.1.1.21 0.810
3m64 393Aldose reductase 1.1.1.21 0.797
1iei ZESAldose reductase 1.1.1.21 0.788
2pdp 393Aldose reductase 1.1.1.21 0.787
3mc5 393Aldose reductase 1.1.1.21 0.778
2pdc 393Aldose reductase 1.1.1.21 0.774
2pzn 393Aldose reductase 1.1.1.21 0.762
2pdu 393Aldose reductase 1.1.1.21 0.756
4gca 2X9Aldose reductase 1.1.1.21 0.732
1t40 ID5Aldose reductase 1.1.1.21 0.716
2inz OHPAldose reductase 1.1.1.21 0.691
3s3g TLTAldose reductase 1.1.1.21 0.681
2pdl TOLAldose reductase 1.1.1.21 0.679
1frb ZSTAldose reductase-related protein 2 / 0.673
2ikh LITAldose reductase 1.1.1.21 0.673
2nvc ITAAldose reductase 1.1.1.21 0.673
4yu1 53NAldose reductase 1.1.1.21 0.672
2pdh 47DAldose reductase 1.1.1.21 0.671
2pdi ZSTAldose reductase 1.1.1.21 0.670
3m0i ZSTAldose reductase 1.1.1.21 0.670
2fz9 ZSTAldose reductase 1.1.1.21 0.668
2iqd LPAAldose reductase 1.1.1.21 0.668
2pdn 47DAldose reductase 1.1.1.21 0.662
2pdg 47DAldose reductase 1.1.1.21 0.659
1pwl BFIAldose reductase 1.1.1.21 0.658
2pdx ZSTAldose reductase 1.1.1.21 0.658
2pdq 47DAldose reductase 1.1.1.21 0.657
2ipw 2CLAldose reductase 1.1.1.21 0.655
2fzb TOLAldose reductase 1.1.1.21 0.651