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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pl0 STI Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 1.127
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.895
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.875
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.874
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.871
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.861
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.858
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.857
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3bv3 P39Mitogen-activated protein kinase 14 / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.734
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.726
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.721
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.719
3gfe P37Mitogen-activated protein kinase 14 / 0.693
4kip 1R9Mitogen-activated protein kinase 14 / 0.688
3bx5 304Mitogen-activated protein kinase 14 / 0.675
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.670
2rg6 287Mitogen-activated protein kinase 14 / 0.669
3mvm 39PMitogen-activated protein kinase 14 / 0.667
2bak AQZMitogen-activated protein kinase 14 / 0.662
2hk5 1BMTyrosine-protein kinase HCK 2.7.10.2 0.662
4a9y AQZMitogen-activated protein kinase 14 / 0.662
4e5f 0N7Polymerase acidic protein / 0.660
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.654