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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdc 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdc 393Aldose reductase 1.1.1.21 1.039
3m64 393Aldose reductase 1.1.1.21 0.991
2ikj 393Aldose reductase 1.1.1.21 0.982
2pdj 393Aldose reductase 1.1.1.21 0.966
2pzn 393Aldose reductase 1.1.1.21 0.952
3mc5 393Aldose reductase 1.1.1.21 0.926
3t42 3T4Aldose reductase 1.1.1.21 0.914
2pdp 393Aldose reductase 1.1.1.21 0.913
2pdu 393Aldose reductase 1.1.1.21 0.838
3m4h 388Aldose reductase 1.1.1.21 0.826
3lbo LDTAldose reductase 1.1.1.21 0.824
3ld5 LDTAldose reductase 1.1.1.21 0.824
3ghs LDTAldose reductase 1.1.1.21 0.820
3lql LDTAldose reductase 1.1.1.21 0.816
3ghu LDTAldose reductase 1.1.1.21 0.808
2i17 LDTAldose reductase 1.1.1.21 0.801
1us0 LDTAldose reductase 1.1.1.21 0.800
2i16 LDTAldose reductase 1.1.1.21 0.800
2pdm ZSTAldose reductase 1.1.1.21 0.796
1t40 ID5Aldose reductase 1.1.1.21 0.794
2iki 388Aldose reductase 1.1.1.21 0.789
3ght LDTAldose reductase 1.1.1.21 0.787
2pdx ZSTAldose reductase 1.1.1.21 0.775
2qxw LDTAldose reductase 1.1.1.21 0.774
3ghr LDTAldose reductase 1.1.1.21 0.774
4yu1 53NAldose reductase 1.1.1.21 0.766
3lz5 LDTAldose reductase 1.1.1.21 0.757
2pdn 47DAldose reductase 1.1.1.21 0.752
3mb9 ZSTAldose reductase 1.1.1.21 0.744
3m0i ZSTAldose reductase 1.1.1.21 0.739
2pdf ZSTAldose reductase 1.1.1.21 0.737
2pdh 47DAldose reductase 1.1.1.21 0.735
2inz OHPAldose reductase 1.1.1.21 0.725
3g5e Q74Aldose reductase 1.1.1.21 0.718
1z3n 3NAAldose reductase 1.1.1.21 0.712
2iqd LPAAldose reductase 1.1.1.21 0.708
2pd5 ZSTAldose reductase 1.1.1.21 0.708
2pdg 47DAldose reductase 1.1.1.21 0.701
3s3g TLTAldose reductase 1.1.1.21 0.700
2dux ZSTAldose reductase 1.1.1.21 0.698
2fz9 ZSTAldose reductase 1.1.1.21 0.697
2ikh LITAldose reductase 1.1.1.21 0.694
2pdq 47DAldose reductase 1.1.1.21 0.687
2hvo ZSTAldose reductase 1.1.1.21 0.682
2duz ZSTAldose reductase 1.1.1.21 0.681
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 0.680
2hv5 ZSTAldose reductase 1.1.1.21 0.678
2pdl TOLAldose reductase 1.1.1.21 0.678
2pdb ZSTAldose reductase 1.1.1.21 0.677
3len ZSTAldose reductase 1.1.1.21 0.670
2fz8 ZSTAldose reductase 1.1.1.21 0.667
1t41 ID5Aldose reductase 1.1.1.21 0.666
2dv0 ZSTAldose reductase 1.1.1.21 0.661
2is7 2CLAldose reductase 1.1.1.21 0.661
1frb ZSTAldose reductase-related protein 2 / 0.654